Insulin-like growth factor (IGF) signaling is thought to play a role in the development and progression of multiple cancer types. To date, therapeutic strategies aimed at disrupting IGF signaling have largely focused on antibodies that target the IGF-I receptor (IGF-IR). Here, we describe the pharmacologic profile of BI 836845, a fully human monoclonal antibody that utilizes an alternative appr...

In this paper, a rational Bézier surface is proposed as a uniform approach to modeling all three types of molecular surfaces (MS): the van der Waals surface (vdWS), solvent accessible surface (SAS) and solvent excluded surface (SES). Each molecular surface can be divided into molecular patches, which can be defined by their boundary arcs. The solution consists of three steps: topology modeling,...

In a preceding paper [6], automata have been introduced for words indexed by linear orderings. These automata are a generalization of automata for finite, infinite, bi-infinite, and even transfinite words studied by Büchi. Kleene’s theorem has been generalized to these words. We show that deterministic automata do not have the same expressive power. Despite this negative result, we prove that r...

In a preceding paper (Bruyère and Carton, automata on linear orderings, MFCS’01), automata have been introduced for words indexed by linear orderings. These automata are a generalization of automata for finite, infinite, bi-infinite and even transfinite words studied by Büchi. Kleene’s theorem has been generalized to these words. We prove that rational sets of words on countable scattered linea...

The classi cation of foliated surfaces, [McQ08], is applied to the study of curves on surfaces with big co-tangent bundle and varying moduli, be it purely in characteristic zero, or, more generally when the characteristic is mixed. Almost everything that one might naively imagine is true, but with one critical exception: rational curves on bi-disc quotients which aren't quotients of products of...

the decomposition $gamma=bh$ of a group $gamma$ into a subset $b$ and a subgroup $h$ of $gamma$ induces, under general conditions, a group-like structure for $b$, known as a gyrogroup. the famous concrete realization of a gyrogroup, which motivated the emergence of gyrogroups into the mainstream, is the space of all relativistically admissible velocities along with a binary operation given by t...

Sleep disordered breathing (SDB) is a frequent finding in the elderly. SDB is related to morbidity, mortality, quality of life, disability, and cognitive impairment. Treatment of choice for SDB is nasal positive airway pressure breathing (nCPAP). The impact of treatment for SDB on activities of daily living (ADLs) is unclear. We therefore investigated the relationship between SDB and ADLs in a ...

Résumé. Dans cet article, nous proposons un système de classification des comptes-rendus mammographiques, reposant sur une ontologie radiologique décrivant les signes radiologiques et les différentes classes de la classification ACR des systèmes BIRADS dans le langage OWL. Le système est conçu pour, extraire les faits issus des textes libres de comptes-rendus en étant dirigé par l’ontologie, pu...

We discuss bribery as a rational behaviour in two player bi-matrix games in game settings, where one player can assign the strategies to the other player. This can be observed as leader (or: Stackelberg) equilibria, where a leader assigns the strategy to herself and to the other player, who follows this lead unless he has an incentive not to. We make the rational assumption that a leader can fu...

In this paper we study cubic del Pezzo fibrations f : X → P such that the 3-fold X is smooth and rkPic(X) = 2. These are the examples of smooth 3-fold Mori fibre spaces. The 3-fold X is a divisor in the linear system |3M + nL| on the rational scroll Proj(⊕ i=1 OP1(di)), where n and di are integers, d1 ≥ d2 ≥ d3 ≥ d4 = 0, M is a tautological line bundle, and L is a fibre of the projection to P. ...