Aberrant expression of ras genes has been recognized in several human cancers and is associated with the development of the disease. Thus, revealing the mechanisms that regulate the expression of ras genes is critical for understanding their role in the process of tumorigenesis. Transcriptional regulation of the H-ras gene, involves nuclear factors recognizing elements in the promoter region of...

To the Editor: The demonstration that cell-free circulating DNA detected in the plasma of cancer patients is genetically identical to that of the primary tumor has generated substantial interest, leading to 200 publications (http:// www.ncbi.nlm.nih.gov). Recently, Wang et al. (1 ) reported in this journal that the method chosen for DNA isolation might contribute significantly to mutation detec...

The induction of mouse skin papillomas by initiation-promotion protocols is associated with aberrant expression of epithelial markers in the tumor mass. Similarly, initiation of mouse keratinocytes with a retrovirus encoding the v-ras gene (v-ras keratinocytes) causes characteristic alterations of epidermal gene expression (A. A. Dlugosz et al., Cancer Res., 54: 6413–6420, 1994). Because activa...

T. K. Rhee, J. K. Park, T. A. Cashen, W. Shin, B. E. Schirf, A. C. Larson, P. V. Prasad, D. Li, T. J. Carroll, R. A. Omary Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States, Biomedical Engineering, Northwestern University, Chicago, Illinois, United States Introduction 3D magnetic resonance angiography (MRA) detection of renal artery stenosis (RAS) ...

A dipose tissue has classically been assumed to function simply as a depot storing excess metabolic fuels that can be mobilized during energy deprivation. It is now well recognized , however, that adipocytes are major players in the regulation of a large number of physiological functions including blood pressure. 1 Among ways, adipocytes influence physiological processes; it is arguably their a...

The role of the renal vasculature in eliciting renovascular hypertension (RVH) was established in 1934, when Goldblatt et al. [1] in a classical experimental study demonstrated that partial obstruction of the renal artery increased mean arterial blood pressure (BP). The pathophysiology of renal artery stenosis (RAS) is incompletely understood but has been postulated to be related to increased a...

Guanine nucleotide exchange factors (GEFs) activate Ras proteins by stimulating the exchange of GTP for GDP in a multistep mechanism which involves binary and ternary complexes between Ras, guanine nucleotide, and GEF. We present fluorescence measurements to define the kinetic constants that characterize the interactions between Ras, GEF, and nucleotides, similar to the characterization of the ...

renal artery stenosis (ras) is the most common cause of secondary hypertension. preliminary data indicate that aspirin renography with hippurate may be more sensitive for detection ras. in this study 20 patients with known or suspected ras underwent aspirin renography (20 mg/kg orally 1 hour before injection of radiotracer) and captopril renography (50 mg orally) with 99mtc-dtpa. renal angiogra...

Abstract The celebrated universal Islamic history, Mīrkhwānd's Tārīkh-i Rauḍat al-ṣafā , written in Herat the late Timurid period, became a model for later Persian histories, but has not yet been subject of any substantial critical analysis as work historical literature, or terms its manuscript transmission. Although numerous copies exist different volumes text, only handful have illustrated, p...

Background: Recurrent aphthous stomatitis (RAS) is among the most common oral lesions and pain is often the chief complaint of patients. The main etiology of RAS is unknown but several predisposing factors have been suggested. This study aims to assess the correlation of blood types (ABO/Rh) with RAS. Methods: We conducted this prospective screening study on 50 patients with RAS and 50 controls...