The existence of over- and under-represented sequence motifs in genomes provides evidence of selective evolutionary pressures on biological mechanisms such as transcription, translation, ligand-substrate binding, and host immunity. In order to accurately identify motifs and other genome-scale patterns of interest, it is essential to be able to generate accurate null models that are appropriate ...

Our study investigates the role of infrastructures in shaping online news usage by contrasting use patterns of two social groups—millennials and boomers—that are specifically located in news infrastructures. Typically based on self-reported data, popular press and academics tend to highlight the generational gap in news usage and link it to divergence in values and preferences of the two age co...

This paper describes a tool that enables instructors to select, visualize and mine students’ usage data in Moodle courses. The tool has been developed in PHP language and integrated in Moodle as a block.

The purpose of the present study was to examine correlates of polypharmacy among underserved community-dwelling older African American adults. Methods. This study recruited 400 underserved older African Americans adults living in South Los Angeles. The structured face-to-face interviews collected data on participants' characteristics and elicited data pertaining to the type, frequency, dosage, ...

The reliability test for embedded software system is very difficult due to its complex structure and large scale. Markov usage model which describes the software usage with Markov process is widely used for statistical test. Software statistical test based on Markov usage model is an effective approach to the generation of test cases with high efficiency and the evaluation of software reliabili...

We present an empirical study about the usage of RNN generative models for stochastic optimization in the context of de novo drug design. We study different kinds of architectures and we find models that can generate molecules with higher values than ones seen in the training set. Our results suggest that we can improve traditional stochastic optimizers, that rely on random perturbations or ran...

The hypothesis that codon usage regulates gene expression at the level of translation is tested. Codon usage of Escherichia coli and phage lambda is compared by correspondence analysis, and the basis of this hypothesis is examined by connecting codon and tRNA distributions to polypeptide elongation kinetics. Both approaches indicate that if codon usage was random tRNA limitation would only affe...

The study of offender trajectories has been a prolific area of criminological research. However, few studies have incorporated the influence of emerging adulthood, a recently identified stage of the life course, on offending trajectories. The present study addressed this shortcoming by introducing the "prolonged adolescent" offender, a low-level offender between the ages of 18 and 25 that has f...

It has been shown that the distribution of genes in eukaryotic genomes is not random; however, formerly reported relations between gene function and genomic organization were relatively weak. Previous studies have demonstrated that codon usage bias is related to all stages of gene expression and to protein function. Here we apply a novel tool for assessing functional relatedness, codon usage fr...

We survey several applications of the differential equation method in different areas of discrete mathematics. We give examples of its use in the analysis of algorithms in random graph processes and random boolean formulae. We also briefly review the basic theorem of Wormald [77] used in the analysis, but we aim for simplicity and not for maximal generality. The primary goal of this survey is t...