Curative radiotherapy is the first choice of therapy for T1 and T2 stage laryngeal squamous cell carcinoma (LSCC) patients to preserve their phonation. Patients with recurrent tumors who undergo salvage surgery require prolonged nasal feeding. Therefore, clinical interest has been focused on elucidating a predictive factor indicating which tumors are likely to be radiosensitive before radiother...

PURPOSE Because of the potential for affecting multiple signaling pathways, inhibition of Hsp90 may provide a strategy for enhancing tumor cell radiosensitivity. Therefore, we have investigated the effects of the orally bioavailable Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) on the radiosensitivity of human tumor cells in vitro and grown as tumor xenografts....

Bloom Syndrome (BS) is a genetic DNA repair disorder, caused by mutations in the BLM gene. The clinical phenotype includes growth retardation, immunodeficiency and strong predisposition to different types of malignancies. Treatment malignancies BS patients with radiotherapy or chemotherapy believed be associated increased toxicity, but laboratory data are lacking. We collected two Dutch solid t...

Therapy of glioblastoma has been very problematic with disappointing results using multiple therapeutic approaches. In general, glioblastomas are considered radioresistant tumors with different radiation modalities failing to control them in the clinic. However a comprehensive and detailed analysis of the radiosensitivity of glioblastoma cells has not been performed. We now present such an anal...

Phosphorylation is an important modification involved in the control of p53 activity. We examined the relationship between p53 phosphorylation and cell radiosensitivity. We prepared H1299 cells (p53-null) with various mutations of p53 at three sites (serine 15, 20 and 46) and examined the radiosensitivity of the cells. In three mutant forms of p53--S15A, S20A and S46A--serine was converted to a...

Metadherin (MTDH) promotes cancer metastasis, chemoresistance, invasion and angiogenesis. Upregulation of MTDH is correlated with both progression and poor clinical outcome of many types of cancers; however, there is currently no information regarding the role of MTDH in radiation sensitivity. Here, we investigated the effects of MTDH on the radio...

While radical cystectomy remains the primary treatment of choice for bladder cancer, increased evidence supports use bladder-preservation strategies based on adjuvant radiotherapy. This highlights need a better understanding cancer radiosensitivity to different types deliveries. The purpose this study is analyze effect time, dose and fractionation number sizes grown three-dimensional (3D) spher...

sarcomas into this scheme, but soon it became apparent that there are carcinomas and sarcomas of different sensitivity; this involved further investigations to trace the origin of these differences with the object of foretelling the radiosensitivity of a tumour from its histological features revealed by biopsies, and of fixing the plan of the treatment according to these findings. The most rema...

Telomere lengths in radiosensitive murine lymphoma cells L5178Y-S and parental radioresistant L5178Y cells were measured by quantitative fluorescence in situ hybridization. Results revealed a 7-fold reduction in telomere length in radiosensitive cells (7 kb) in comparison with radioresistant cells (48 kb). Therefore, it was reasoned that telomere length might be used as a marker for chromosomal...

I N VIEW OF THE FUNCTION of hemopoietic stem cells maintaining a hematologically steady state, radiosensitivity of the stem cells has been regarded as responsible for postirradiation hemopoietic death. As a method for studying the effect of irradiation upon hematopoietic stem cells, the colonyforming cells first described by Till and McCulloch’ 3 and the erythropoietin responsive cells in polyc...