LPS is radioprotective in the mouse small intestine through a mechanism that includes the synthesis of cyclooxygenase-2 (COX-2) and PGE2. The goal of this study was to identify the intermediate steps in this process. We used wild-type (WT) C57BL/6 mice and knockouts for tumor necrosis factor receptors 1 and 2 (TNFR1-/-, TNFR2-/-) and recombination-activating gene 1-/- mice. Mice were given pare...

A novel approach to measure the time course of paramagnetic spin probe concentration in the circulating blood of a living mouse using X-band (9.4 GHz) electron paramagnetic resonance spectrometer is described. Using this technique, the pharmacokinetics of several nitroxyl spin probes was examined. The decay profiles were also independently simulated using pharmacokinetic properties as well as r...

Lipopolysaccharide (LPS) is radioprotective in the mouse small intestine through a mechanism that includes the synthesis of cyclooxygenase-2 (Cox-2) and prostaglandin (PGE2). The goal of this study was to identify the intermediate steps in this process. We used wild type (WT) C57BL/6 mice and knockouts for tumor necrosis factor receptors 1 and 2 (TNFR1 -/-, TNFR2-/-) and RAG-1 -/mice. Mice were...

To determine the effects of steel factor (SIF) on the number and distribution of phenotypically defined hematopoietic stem cells in vivo, mice were treated with continuous s.c. infusions of SIF for up to 7 days. The bone marrow demonstrated a transient 5-fold increase in the number of c-kit-positive lineage-negative/low cells with no change in cellularity. The radioprotective capacity of bone m...

  Background: A radioprotective effect of amifostine as well as its ability to modulate the level of spontaneous and gamma-irradiation-induced genetic changes on human peripheral blood lymphocytes has been investigated . Amifostine, known as a potent radical scavenger, has been introduced as the most effective radioprotector, yet it is not completely approved for the clinical use. However, furt...

This is the second article published in the Trees for Life Journal which deals with radioprotection (see http://www. tfljournal.org/article.php/2007042416194363 by Sancheti and Goyal). While it is not a major focus of this journal, radioprotection has interest for our readership and is attracting ever more attention within the scientific community. No synthetic radioprotective chemicals are ava...