introduction: bleomycins are dna-binding biomolecules, which can be used as targeted therapy carriers when labeled with particle-emitters such as yb-175. in this work the development of yb-175 bleomycin (175yb-blm) has been reported. methods: yb-175 chloride was obtained by thermal neutron irradiation (3 × 1013 n.cm-2.s-1) of natural yb2o3 samples at various neutron fluxes and irradiation time...

Introduction: Somatostatin receptors expressed on a wide range of human tumors, are potential targets for the peptide receptor radionuclide therapy (PRRT). In this study, 177Lu-[DOTA-DPhe1, Tyr3]octreotide (177Lu-DOTATOC) as an agent for PRRT was prepared and its biodistribution was studied in rats. Methods:The ...

background: due to the evacuation of some industrial wastewaters to arvandrood, the presence of the radionuclide material in the river is likely. the purpose of this study was to determine the radioactivity rate in arvandrood land area to the persian gulf. methods: : the concentration of cesium radionuclide (cs137) was measured in 20 sediment samples and 8 water samples which were collected fro...

A microwave-assisted synthesis of cisplatin, cis-[Pt(NH3)2Cl2], has been developed and optimized on both a 0.2 and 0.05 millimolar scale. The optimized synthetic procedure was modeled after the Lebedinskii-Golovnya method and is suitable for incorporating the radionuclide, (195m)Pt, into cisplatin for biological studies. Highest yields (47%) and purity are obtained using a K2PtCl4 : NH4OAc : KC...

The relatively long-lived positron emitters Cu (t1/2 = 12.7 h), Br (t1/2 = 16.2 h) and I (t1/2 = 4.18 d) are finding increasing applications in positron emission tomography (PET). For precise determination of their positron emission intensities, each radionuclide was prepared via a charged particle induced reaction in a “no-carrier-added” form and with high radionuclidic purity. It was then sub...

Introduction: Rheumatoid arthritis (RA) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. Radiosynovectomy (RSV) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. Se...

[(11)C]-choline is an effective PET tracer used for imaging of neoplastic lesions and metastases of the prostate cancer. However, its production can be a challenge for manufacturers, as it has not yet been described in Polish or European pharmacopoeia. In this study the technical aspects of [(11)C]-choline production are described and detailed process parameters are provided. The quality contro...

A microwave-assisted synthesis of cisplatin, cis-[Pt(NH3)2Cl2], has been developed and optimized on both a 0.2 and 0.05 millimolar scale. The optimized synthetic procedure was modeled after the Lebedinskii-Golovnya method and is suitable for incorporating the radionuclide, Pt, into cisplatin for biological studies. Highest yields (47 %) and purity are obtained using a K2PtCl4:NH4OAc:KCl molar r...

Introduction: Bleomycins are DNA-binding biomolecules, which can be used as targeted therapy carriers when labeled with particle-emitters such as Yb-175. In this work the development of Yb-175 bleomycin (Yb-BLM) has been reported. Methods: Yb-175 chloride was obtained by thermal neutron irradiation (3 × 10 n.cm.s) of natural Yb2O3 samples at various neutron fluxes and irradiation times. The rad...

Introduction: Bleomycins are DNA-binding biomolecules, which can be used as targeted therapy carriers when labeled with particle-emitters such as Yb-175. In this work the development of Yb-175 bleomycin (175Yb-BLM) has been reported. Methods: Yb-175 chloride was obtained by thermal neutron irradiation (3 × 1013 n.cm-2.s-1) of natural Yb2O<...