objective(s): the objectives of this work was to assess the benefits of the application of physiologically based pharmacokinetic (pbpk) models in patients with different neuroendocrine tumours (net) who were treatedwith lu-177 dotatate. the model utilises clinical data on biodistribution of radiolabeled peptides (rlps) obtained by whole body scintigraphy (wbs) of the patients.methods: the blood...

The vectorial translocation of nascent proteins through the membrane of the rough endoplasmic reticulum has been shown to require a specific membrane-bound protein whose cytoplasmic domain can be proteolytically cleaved and isolated as an active peptide of mol wt 60,000 (Meyer and Dobberstein, 1980, J. Cell Biol. 87:503-508). Rabbit antibodies raised against this peptide were used to further ch...

PURPOSE The early detection and diagnosis of pancreatic cancer remains a major clinical challenge in which imaging procedures have a central role. The purpose of this study was to evaluate a pretargeting method with a bispecific PAM4 (bsPAM4; anti-MUC1) antibody for radioimmunoscintigraphy of experimental human pancreatic cancer. EXPERIMENTAL DESIGN A bispecific F(ab')(2) antibody was generat...

The v 3 integrin is expressed on proliferating endothelial cells such as those present in growing tumors, as well as on tumor cells of various origin. Tumor-induced angiogenesis can be blocked in vivo by antagonizing the v 3 integrin with small peptides containing the Arg-Gly-Asp (RGD) amino acid sequence. This tripeptidic sequence, naturally present in extracellular matrix proteins, is the pri...

Promotiecommissie Promotoren: Chapter 1 General Introduction: Improvement strategies for peptide receptor scintigraphy and radionuclide therapy. 7 Part I Neurotensin analogs for in vivo targeting of exocrine pancreatic cancer Chapter 2 Stabilised 111 In-labeled DTPA-and DOTA-conjugated neurotensin analogs for imaging and therapy of exocrine pancreatic cancer. 43 Chapter 3 Five stabilized 111 In...

In this issue of The Journal of Nuclear Medicine, Wild et al. report the binding and animal biodistribution data of [Lys(Ahx-DTPA-In)NH2]exendin-4 (Ahx is aminohexanoic acid; DTPA is diethylenetriaminepentaacetic acid), an analog of glucagonlike peptide-1 (GLP-1) (1). Their results raise high hopes of actually achieving selective and potent receptormediated targeting of tumors with a radiolabel...

We have previously identified three distinctive amino acid sequences from type IV collagen which specifically bound to heparin and also inhibited the binding of heparin to intact type IV collagen. One of these chemically synthesized domains, peptide Hep-I, has the sequence TAGSCLRKFSTM and originates from the a1(noncollagenous [NC1]) chain of type IV collagen (Koliakos, G. G., K. K. Koliakos, L...

Introduction: Neurotensin (NT) is a tridecapeptide that binds specifically to neurotensin receptors. Several forms of cancer, including small cell lung cancer, colon, pancreatic and prostate carcinomas especially exocrine pancreatic carcinomas express receptors for neurotensin peptide. Radiolabeled neurotensin derivatives with a high affinity for these receptors might be used for scintigraphy. ...