Radioembolization (RE) of liver cancer with (90)Y-microspheres has been applied in the last two decades with notable responses and acceptable toxicity. Two types of microspheres are available, glass and resin, the main difference being the activity/sphere. Generally, administered activities are established by empirical methods and differ for the two types. Treatment planning based on dosimetry ...

PURPOSE Once implanted, prostate brachytherapy seeds are vulnerable to loss and movement. A general estimation of these effects may be useful for making patient care decisions when seeds are lost after the post-implant scan. The goal of this work was to explore the dosimetric and radiobiological effects of the types of seed loss and migration common in prostate brachytherapy. METHODS This stu...

AIM OF THE STUDY Aim of the study was to compare radiobiological effects of multiple vs. single low-dose pre-irradiation on the HT29 cell line. This regime is designed to be as similar as possible to fractionated tumour radiotherapy treatment, and to provide data on radiobiological effects on human tumour cells. MATERIAL AND METHODS The cell line used in the study was HT29 (human colorectal a...

Proton therapy represents a technologically advanced method for delivery of radiation treatments to tumors. The determination the biological effectiveness is one objectives MoVe IT (Modeling and Verification Ion Beam Treatment Planning) project National Institute Nuclear Physics (INFN) CSN5. aim present work, which part project, was evaluate performance thermoluminescent dosimeters (TLDs-100) d...

In view of the emerging interest of carbon ions in radiotherapy and of the strong correlation between the track structure and the radiobiological effectiveness of ionising radiations, the track-structure properties of (12)C-ions were studied at particle energies close to the Bragg peak. To perform the investigations, ionisation-cluster-size distributions for nanometre-sized target volumes were ...

In radiotherapy, tumors are irradiated with a high dose, while surrounding healthy tissues are spared. To quantify the probability that a tumor is effectively treated with a given dose, statistical models were built and employed in clinical research. These are called tumor control probability (TCP) models. Recently, TCP models started incorporating additional information from imaging modalities...

Radiation studies of vaccinia virus were carried out using two types of radiation, Coao gamma rays and ultraviolet light (UVL). When virus particles were irradiated with gamma rays a two-component survival curve was obtained. The capacity of Earle’s L cells to support the growth of vaccinia virus was relatively sensitive to gamma rays. Infectious centres formed by infecting L cells with vaccini...

background: increasing the complexity in modern radiotherapy techniques have increased the delivery time lowering consequently the treatment efficacy. through simulating the delivery time delay encountered in such techniques, its’ effect on two cancer cell lines and the compensating doses given to prevent such effect was investigated. materials and methods: f10b16 and 4t1 cancer cell lines were...