Date The final copy of this thesis has been examined by the signatories, and we find that both the content and the form meet acceptable presentation standards of scholarly work in the above mentioned discipline. The multiresolution estimator, originally a wavelet-based method for density estimation, was recently extended for estimation of hazard functions. The multiresolution hazard (MRH) metho...

Natural killer (NK) cells belong to the innate arm of the immune system and though activated NK cells can modulate immune responses through the secretion of cytokines, their primary effector function is through target cell lysis. Accordingly, cytotoxicity assays are central to studying NK cell function. The 51Chromium release assay, is the "gold standard" for cytotoxicity assay, however, due to...

The chromium-release assay developed in 1968 is still the most commonly used method to measure cytotoxicity by T cells and by natural killer cells. Target cells are loaded in vitro with radioactive chromium and lysis is determined by measuring chromium in the supernatant released by dying cells. Since then, alternative methods have been developed using different markers of target cell viability...

The release of radioactive amino acid from the particulate fractions separated from the prelabelled livers of rats by centrifugation has been studied under various conditions. Although pure fractions may not have been obtained, great differences in behavior were observed. In the mitochondria and nuclei dinitrophenol (10(-4)M) causes an inhibition of release, but in microsomes the opposite effec...

The release of radioactive amino add from the particulate fractions separated from the prelabeUed livers of rats by centrifugation has been studied under various conditions. Although pure fractions may not have been obtained, great differences in behavior were observed. In the mitochondria and nuclei dinitrophenol (10 -4 ~) causes an inhibition of release, but in microsomes the opposite effect ...

Disposal facilities for radioactive wastes comprise a series of engineered and natural (geologic) barriers to contain the radionuclides until their radiation hazard has decreased to acceptable levels. It is required that the long-term functionality of the containment barriers be evaluated by a quantitative risk analysis, also termed performance assessment. This entails the implementation of a P...