BACKGROUND The efficacies of adjuvant stereotactic radiosurgery (SRS) and external beam radiation therapy (EBRT) for atypical meningiomas (AMs) after subtotal resection (STR) remain unclear. OBJECTIVE To analyze the clinical, histopathological, and radiographic features associated with progression in AM patients after STR. METHODS Fifty-nine primary AMs after STR were examined for predictor...

BACKGROUND Late radiation tissue injury is a serious complication of radiotherapy for patients with gynecologic malignancies. Strategies for managing pain and other clinical features have limited efficacy; however, hyperbaric oxygen therapy (HBO(2)) may be an effective option for some patients. METHODS In a systematic review of the literature, the Ovid medline, embase, Cochrane Library, Natio...

BACKGROUND Bevacizumab has been suggested as a new treatment modality for cerebral radiation necrosis due to its ability to block the effects of vascular endothelial growth factor (VEGF) in leakage-prone capillaries, though its use still remains controversial in clinical practice. METHODS The use of bevacizumab in 17 patients with symptomatic cerebral radiation necrosis poorly controlled with...

Hyperbaric oxygen therapy (HBO), the administration of 100% oxygen under high pressure, can improve the situation. Such therapy greatly increases the amount of oxygen availabile to tissue. This is due to the gaseous/fluid (oxygen/plasma) interface that enhances oxygen absorption and transportation into the liquid phase of the blood. Under such circumstances, repair of tissue damaged by high dos...

A 63-year-old man developed delayed cerebral radiation necrosis following radiotherapy to a nasopharyngeal carcinoma. Complete resolution of his neurological deficit resulted from corticosteroid therapy alone. Serial CT scans showed the disappearance of the patients' mass lesion. The literature on cerebral necrosis following radiotherapy of extracranial neoplasms is reviewed with particular emp...

This case report suggests that magnetic resonance imaging with diffusion weighted imaging may help distinguish between tumour recurrence and radiation induced necrosis in patients previously treated for a brain tumour.

A 55-year-old woman underwent radiosurgery for a left cerebral hemisphere arteriovenous malformation (AVM) and developed radiation-induced necrosis causing a massive edema in the surrounding brain tissues. Despite various therapies, the edema expanded to the ipsilateral hemisphere and induced neurological symptoms. The radiation-induced necrotic lesion was surgically removed 4 years after radio...

A patient who had previously undergone resection of a malignant glioma followed by radiation therapy was found to have a focus of a high accumulation of thallous chloride Tl 201 on single-photon emission CT scans, suggesting recurrent tumor. Resection of this area was performed and the specimen showed radiation necrosis, including such reactive changes as reactive astrocytes and lymphocytes in ...