نتایج جستجو برای: r42
تعداد نتایج: 53 فیلتر نتایج به سال:
Crystallographic studies of the past ten years have revealed that many outer membrane proteins and bacterial toxins are constructed on the b-barrel motif. Two structural classes can be identified. The first class, represented by the porins, includes monomeric or multimeric proteins where each b-barrel is formed from a single polypeptide. The second class features proteins where the b-barrel is ...
Purpose:The therapeutic efficacy of a unique melanoma-targeting peptide conjugated with an in vivo generated a-particle-emitting radionuclide was evaluated in the B16/F1mouse melanoma animal model. a-Radiation is densely ionizing, resulting in high concentrations of destructive radicals and irreparable DNA double-strand breaks. This high linear energy transfer overcomes radiation-resistant tumo...
Body: Background: Mtb is the leading cause of death from infection. Essential enzymes that have not yet been targeted in Mtb include those that synthesize Coenzyme A (CoA) and phosphopantetheinyl transferase (PptT). PptT transfers phosphopantetheine from CoA to acyl carrier proteins (Acps) involved in synthesis of cell wall lipids, siderophores and virulence factors. Methods: Screening identifi...
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