BACKGROUND Chronic lung disease resulting from dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) and NFκB-mediated neutrophilic-inflammation forms the basis of CF-related mortality. Here we aimed to evaluate if HDAC inhibition controls Pseudomonas-aeruginosa-lipopolysaccharide (Pa-LPS) induced airway inflammation and CF-lung disease. METHODS For in vitro experiments, HE...

14-3-3σ overexpression results in enhanced hepatocellular carcinoma (HCC) cell migration and HCC tumor vascular-invasion is significantly associated with 14-3-3σ expression. However, increased expression of 14-3-3σ paradoxically suppresses in vitro cell invasion of HCC. We hypothesize that surrounding tumor-associated stromal cells play a crucial role in 14-3-3σ-regulated HCC cell invasion. In ...

OBJECTIVES The purpose of this research was to determine the phenotypic spectrum associated with phospholamban gene (PLN) mutations. BACKGROUND Inheritance contributes to the development of dilated cardiomyopathy. Mutations in the gene encoding PLN have been associated with dilated cardiomyopathy characterized by early onset and the presence of lethal ventricular arrhythmias. METHODS We scr...

The holdout problem is commonly cited as the justification for eminent domain, but the nature of the problem is not well understood. This paper models the holdout problem in a bargaining framework, where a developer seeks to acquire several parcels of land for a large-scale development. We show that in the absence of eminent domain, holdouts are inevitable, threatening costly delay. However, if...

This paper studies the effect of terrorist attacks on the internal structure of cities. We develop an urban framework with capital structures suitable for the study of this question and analyze the long and short term implications of this type of events. In the long run, the analysis shows that a terrorist attack will affect urban structure only modestly, relative to the potentially large decre...

An index of ‘deforestation pressure’ is suggested as useful for reserve planning alongside the currently used information on the species present at candidate sites. For any location, the index value is correlated with threats to habitat and thus also survival probabilities over time for members of species dependent on that habitat. Threats in the absence of reserves are key information for plan...

Pathogenicity and anastomosis groups of seven Rhizoctonia-like isolates obtained from infected pistachio (Pistacia vera L.) seedlings were determined, in the central district Siirt province at Southeast Anatolia Region Turkey. Browning on crown root collected saplings drying plants observed. In pathogenicity test, most virulent isolate was Rs2 with a disease severity 93.75%. The group this isol...