نتایج جستجو برای: r12
تعداد نتایج: 486 فیلتر نتایج به سال:
CXCR4 is a coreceptor of HIV-1 infection in host cells. Through a photocrosslinking study to identify receptors involved in internalization of oligoarginine cell-penetrating peptides (CPPs), we found that CXCR4 serves as a receptor that stimulates macropinocytic uptake of the arginine 12-mer peptide (R12) but not of the 8-mer. We also found that stimulating CXCR4 with its intrinsic ligands, str...
not only satisfies all the cusp conditions (as promised by Hirschfelder) but provides a satisfying variational form for obtaining quite high accuracy predicted energies of the Helium 1S 2-electron ground state. It employs a “to be determined” function g(r1,r2,r12) to correct for all the errors induced by the cusp determined functions (i. e., those functions chosen to make sure that the total An...
in the fundamental representation. Conspicuously absent from this list is A (1) n for n > 1. This is because in order to demonstrate integrability, we assume that the corresponding R matrix has crossing symmetry, which is not true in the case A (1) n for n > 1. Sklyanin has demonstrated that an integrable open spin chain can be constructed with an R matrix that satisfies nothing more than the Y...
BACKGROUND Fascioliasis is a severe zoonotic disease of worldwide extension caused by liver flukes. In human fascioliasis hyperendemic areas, reinfection and chronicity are the norm and anemia is the main sign. Herein, the profile of the Th1/Th2/Th17/Treg expression levels is analyzed after reinfection, correlating them with their corresponding hematological biomarkers of morbidity. METHODOLO...
Superheated drops are known to vaporise when exposed to energetic nuclear radiation since the discovery of bubble chamber. The application of superheated drops in neutron research specially in neutron dosimetry is a subject of intense research for quite sometime. As the degree of superheat increases in a given liquid, less and less energetic neutrons are required to cause nucleation. This prope...
Prion proteins (PrPs) cause prion diseases, such as bovine spongiform encephalopathy. The conversion of a normal cellular form (PrP(C)) of PrP into an abnormal form (PrP(Sc)) is thought to be associated with the pathogenesis. An RNA aptamer that tightly binds to and stabilizes PrP(C) is expected to block this conversion and to thereby prevent prion diseases. Here, we show that an RNA aptamer co...
Colorectal carcinomas (CRCs) with high-level microsatellite instability (MSI-H) often contain gene fusions, which involve receptor tyrosine kinases. This study included 105 MSI-H CRCs. NTRK1/2/3, ALK, ROS1 and RET fusions were analyzed by PCR test for 5’/3’-end unbalanced expression, is capable of detecting all translocation variants. The type rearrangements was subsequently determined variant-...
Deinococcus wulumuqiensis R12, isolated from radiation-polluted soil, is a red-pigmented strain of the extremely radioresistant genus Deinococcus. It contains a major carotenoid, namely, deinoxanthin. Here, we present a 3.39-Mb assembly of its genome sequence, which might provide various kinds of useful information related to Deinococcus, such as about the key enzymes of its radioresistance mec...
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