Tau, a natively unstructured protein that regulates the organization of neuronal microtubules, is also found in high concentrations in neurofibrillary tangles of Alzheimer's disease and other neurodegenerative disorders. The conformational transition between these vastly different healthy and pathological forms remains poorly understood. We have measured residual dipolar couplings (RDCs), J-cou...

Ozonolysis is a major removal mechanism in the troposphere for unsaturated hydrocarbons which are emitted in large quantities from both natural and human sources. Now it is generally accepted that ozonolysis of alkenes proceeds via Criegee intermediates, highly reactive species postulated in 1949 by Rudolf Criegee. In the troposphere, Criegee intermediates are involved in several important atmo...

The present study is aimed at alteration of sewage sludge into stable compost product using vermicomposting of sewage sludge mixed with cattle manure and saw dust in five different proportions based on C/N ratios (C/N 15 (R1), 20 (R2), 25 (R3) and 30 (R4); and control (R5)) by employing an epigeic earthworm Eisenia fetida. Higher reductions in C/N ratio, CO2 evolution and OUR were observed in R...

Equivalent faults inhibit fault diagnosis by producing indistinguishable test metric measurements. Removal of conditions causing the equivalence in response exhibited by such faults is necessary if fault diagnosis quality is to be improved. As Design-for-Testability methodology aims to deliver a degree of fault diagnosis substantially greater than that obtainable testing unassisted by on-chip t...

This study compared the effectiveness of the multifocal visual evoked cortical potentials (mfVEP) elicited by pattern pulse stimulation with that of pattern reversal in producing reliable responses (signal-to-noise ratio >1.359). Participants were 14 healthy subjects. Visual stimulation was obtained using a 60-sector dartboard display consisting of 6 concentric rings presented in either pulse o...

BACKGROUND To assess the prevalence of exercise-associated hyponatremia (EAH) in two 24-hour mountain bike (MTB) (R1,R2), one 24-hour running (R3) and one multi-stage MTB (R4) races held in the Czech Republic in a cluster of four cross-sectional studies. METHODS In 27 ultra-mountain bikers (ultra-MTBers), 12 ultra-runners, and 14 multi-stage MTBers, fluid intake, changes (Δ) in body mass, hem...

The objective of this study was to evaluate the effect hydrothermal pretreatment (HTP) at 90, 125 and 155 °C on extent anaerobic digestion (AD) sewage sludge, energy balance, distribution availability N P. AD evaluated with four bench-scale mesophilic, semi-continuous digesters 20-d (Phase 1) 10-d 2) solids retention time (SRT), fed raw sludge (R1), 90 (R2), (R3) (R4) HTP sludge. two mixtures u...

ion f belonging to such a set, for any ground theorem ', exists in 2 a proof 2 of the abstracted theorem f('); moreover exists (at least) one way to \map back" (at least one of the possible) 2 to 1 which gives rise to an outline of the ground proof. can be subsequently re ned. It is important to observe that in interactive abstract theorem proving there is no need to interact only with human be...