Abstract A highly efficient and catalyst-free protocol is reported for the synthesis of quinoxalines via classical cyclocondensation reaction between aryldiamines dicarbonyl compounds. Remarkably simple green conditions employing methanol as solvent afforded medium to excellent yield after only one-minute time at ambient temperature. The allow least 10 gram scale should be a preferred starting ...

Acenaphtho derivatives have been reported as antitumor agents. So, the reaction of acenaphthylene-1,2-dione with 3,4-diaminobenzenethiol, and then with the alkyl chloride derivatives for the synthesis of acenaphtho [1,2-b] quinoxalines are reviewed. Excellent yields of the products, short reaction times and simple work-up are attractive features of this suitable protocol.

We report a suitable quinoxaline synthesis using molybdophosphovanadates supported on commercial alumina cylinders as catalysts. These catalysts were prepared by incipient wetness impregnation. The catalytic test was performed under different reaction conditions in order to know the performance of the synthesized catalysts. The method shows high yields of quinoxaline derivatives under heterogen...

The reaction of 3-mercaptopropylsilica (MPS) and chlorosulfonic acid in chloroform afforded silica bonded S-sulfonic acid (SBSSA), which was used as a catalyst for the room temperature synthesis of quinoxaline derivatives from 1,2-diamino compounds and 1,2-dicarbonyl compounds. The catalyst could be recycled and reused several times without any loss of efficiency.

In this study, we have developed an efficient protocol for synthesis of phosphorus-substituted heterocycles through reaction between 2-Aryl quinoxalines and dialkyl phosphites under transition-metal-free conditions. Here, K2S2O8 has been used as the sole oxidant facile phosphorus substituted derivates. A variety heteroaryl phosphonate derivatives synthesized optimized conditions in good to exce...

Starting from 1-benzyl- (2a) and 1-benzoyl-3-bromoacetyl indoles (2b) new heterocyclic, 2-thioxoimidazolidine (4a, b), imidazolidine-2,4-dione (5a, b), pyrano(2,3-d)imida-zole (8a, b and 9a, b), 2-substituted quinoxaline (11a, b-17a, b) and triazolo(4,3-a)quinoxaline derivatives (18a, b and 19a, b) were synthesized and evaluated for their antimicrobial and anticancer activities. Antimicrobial a...