The presence of an α-1,6-glucosaccharide enhances absorption of water-soluble quercetin glycosides, a mixture of quercetin-3-O-β-d-glucoside (Q3G, 31.8%), mono (23.3%), di (20.3%) and more d-glucose adducts with α-1,4-linkage to a d-glucose moiety of Q3G, in a ligated small intestinal loop of anesthetized rats. We prepared α-1,6-glucosaccharides with different degrees of polymerization (DP) enz...

Biotransformation of exogenous substrates quercetin, kaempferol and apigenin by suspension cultures Astragalus vesicarius ssp. carniolicus to their monoglycosylated derivatives was performed. The maximal enzymatic potential cells A. evaluated different concentrations substrate exposure. According quantitative ultra-high performance liquid chromatography-high resolution electrospray ionization m...

Quercetin and gallic acid are natural activators of the transcription factor Nrf2, which regulates the expression of many cytoprotective enzymes including heme oxygenase-1 (HO-1). We developed procedures for the synthesis of monogalloyl esters of quercetin and taxifolin (dihydroquercetin), namely, 3-O-galloylquercetin and 7-O-galloyltaxifolin, and examined their effect on the Nrf2 pathway in RA...

In recent years, there is an increasing interest in antioxidants. The main reason for this interest is the protection of cells, their organelles (especially membranes) and metabolic pathways against oxygen free radicals and their reactive derivatives (ROS). They participate in formation of chronic inflammation states and other diseases associated with oxidative stress, such as cancer, hypertens...

The overproduction of reactive oxygen species and the exposure human body to free radicals contribute aetiology many chronic health problems, such as cardiovascular disease cancer. Supplementation with natural antioxidants could be helpful, preventing free-radical-induced tissue damage through inhibition radicals’ formation. Quercetin derivatives have recently been shown inhibit production infl...

BACKGROUND/OBJECTIVES Mulberry leaves contain quercetin derivatives, which have the effects of reducing obesity and improving lipid and glucose metabolism in mice with obesity. It is not clear whether or not mulberry leaves can directly affect metabolic disorders, in the presence of obesity, because of the interaction between obesity and metabolic disorders. The aim of the current study was to ...

Cellular oxidative stress causes detrimental effects to macromolecules, such as lipids, nucleic acids and proteins, leading to many pathological conditions. Quercetin-3-O-glucoside (Q3G), a glycosylated derivative of quercetin (Q), is a natural polyphenolic compound known to possess antioxidant activity. The hydrophilic/lipophilic nature of an antioxidant molecule is considered as an important ...