PURPOSE To study the potential combined application of gadolinium and magnetization transfer in the MR imaging of intracranial tumors. METHODS Twenty-two patients were imaged at low field strength (0.1 T). Corresponding gradient-echo partial saturation images without and with magnetization transfer pulse were produced. Images with intermediate repetition times were obtained in 18 cases; five ...

BACKGROUND Neuroimaging studies suggest that schizophrenia is associated with gray and possibly white matter changes. It is unclear whether these changes are present at illness onset or which brain structures are selectively affected. New imaging methods such as magnetization transfer imaging may be more sensitive than conventional volumetric imaging to the subtle structural brain changes in sc...

Introduction: To obtain accurate quantitative perfusion data, continuous arterial spin labeling (CASL) requires balancing magnetization transfer (MT) effects in the control and tag experiments. Traditionally, this is done by applying RF pulses in control experiments that are placed at equal distance as the tag pulse to the imaging slice, but distal to the imaging slice of interest and far enoug...

One of several techniques that achieve contrast by preparing the magnetization in some way and then sampling the prepared magnetization via a conventional imaging sequence, magnetization transfer offers advantages that have proven valuable in the study of white matter disorders. In the most common implementation, the magnetization transfer preparation is integrated into a gradient echo pulse se...

PURPOSE To estimate the age of cerebral infarcts using magnetization transfer. METHODS Twelve patients with radiographically and clinically documented cortical and subcortical cerebral infarctions underwent MR imaging on a 0.1T magnet. Magnetization transfer contrast images were generated by application of off-resonance pulses to every other repetition time on intermediate-weighted images. Th...

BACKGROUND AND PURPOSE Most traumatic brain injuries are classified as mild, yet in many instances cognitive deficits result. The purpose of this study was to investigate possible relationships between quantitative magnetization transfer imaging (MTI) and neurocognitive findings in a cohort of patients with mild head trauma but negative findings on conventional MR images. METHODS We examined ...

Differentiation of cerebral tumor pathology currently relies on interpretation of conventional structural MRI and in some cases histology. However, more advanced MRI methods may provide further insight into the organization of cerebral tumors and have the potential to aid diagnosis. The objective of this study was to use multimodal quantitative MRI to measure the imaging signatures of meningiom...

PURPOSE To determine whether magnetization transfer contrast can differentiate acute from chronic lesions in multiple sclerosis. METHODS Thirteen patients with multiple sclerosis and eight healthy patients were studied with MR using a 0.1-T system. Relatively T2-weighted spin-echo images were obtained without and with magnetization transfer contrast. The magnetization transfer effect of multi...

PURPOSE To determine whether magnetization transfer imaging can improve visibility of contrast enhancement of multiple sclerosis plaques. METHODS Fifty-nine enhancing and 63 nonenhancing lesions in 10 patients with multiple sclerosis were evaluated to calculate contrast-to-noise ratios on conventional T1-weighted and T1-weighted magnetization transfer images. The signal intensity of the lesio...