Increased QT dispersion seems to be related to an increased risk of arrhythmia and sudden death, a common cause of mortality in hemodialysis (HD) patients. Increase in sympathetic tone has been documented in HD patients. In this study, we aimed to investigate the effect of changes in the autonomic tone on QT dispersion (QTd) in HD patients. Twenty HD patients (M/F 13/7; age, mean ±SD, 28 ± 10 y...

Background Anthracyclines are important components of many chemotherapeutic protocols. The present study aimed to evaluate the repolarization changes in electrocardiography (ECG) which may predict drug induced arrhythmia. Materials and Methods In this cross-sectional study, the recorded ECGs were assessed for QT dispersion (QTd), QT corrected dispersion (QTcd), T peak to Tend dispersion (TPe...

conclusions right ventricular pacing increases the qt interval without increasing the jt interval. our results confirm that jtc, as an index of repolarization, is independent of ventricular depolarization. therefore, it can be applied for predicting qtc in patients with lbbb. results stimulation from the rva increased the qtc from 456.20 ± 38.63 ms to 530.67 ± 47.73 ms at a cl of 600 (p < 0.000...

OBJECTIVES To introduce a nomogram of the normal QT interval at various heart rates measured from 24 hour Holter ECG recordings in healthy subjects with respect to age and sex and to use the nomogram to characterise dynamic changes in QT interval in patients with idiopathic ventricular fibrillation (IVF) and the long QT syndrome (LQT). METHODS The study group consisted of 422 subjects: 249 he...

PURPOSE To evaluate the effects of sunitinib, a multitargeted tyrosine kinase inhibitor, on the QT interval in patients with cancer. EXPERIMENTAL DESIGN Patients received sunitinib loading doses (150-200 mg) on days 3 and 9 and maintenance doses (50 mg/d) on days 4 to 8. Moxifloxacin (day 1), placebo (day 2), and granisetron [with placebo (day 2) or sunitinib (days 3 and 9)] were also adminis...

The difference between the maximum and minimum QT interval measured from a 12-lead electrocardiogram was defined as an index of spatial inhomogeneous repolarization of the ventricular myocardium. The causal relationship between QT dispersion and incidence of ventricular arrhythmias has been pointed out in various heart diseases, but until now it was discussed mainly related to sinus rhythm. QT ...

To assess the role of insulin in ventricular repolarization in patients with congenital long QT syndrome (LQTS), an oral glucose tolerance (OGT) test was performed in 11 patients with LQTS and in 11 control cases without QT prolongation. Plasma glucose, potassium level and the immunoreactive insulin concentration (IRI) were measured, and the QT interval and T wave morphology on 12-lead ECG were...

BACKGROUND Restitution through intracardiac pacing has been used to assess arrhythmia vulnerability. We examined whether analyses of sequential beat-to-beat QT and TQ interval measures can be used to quantify ECG restitution changes under normal sinus rhythm. METHODS The QT, R-R and TQ intervals were examined 22.5 hour Holter monitoring before and after oral sotalol in normal male and female ...

15 Alterations in ECG QT intervals correlate with the risk of potentially fatal arrhythmias, for which 16 transgenic murine hearts are becoming increasingly useful experimental models. However, QT 17 intervals are poorly defined in murine ECGs. As a consequence, several different techniques have 18 been used to measure murine QT intervals. The present work develops a consistent measure of murin...

OBJECTIVE Intense emotions are known triggers of sudden cardiac death. However, the effect of typical daily emotion on repolarization has not been examined. We examined whether QT interval changes as a function of typical daily emotion in patients at risk for cardiac events in the context of emotion. METHODS We studied 161 patients (n = 114 females; mean age, 35 years) with the congenital for...