Burkitt's lymphomas (BL) are aggressive rapidly growing tumors typified by a high c-myc expression resulting from t(8;14)(q24;q32), t(2;8)(p12;q24) or t(8;22)(q24;q11) translocations. Alterations of the p53 tumor suppressor are also relatively frequent in BL. Several approaches have been adopted for detection of the p53 aberrations such as immunohistochemical analyses, immunoblotting, DNA seque...

Recurring, site-specific chromosomal rearrangements are associated with several human syndromes and malignant disorders. Such nonrandom translocations involving chromosome 22 in band q11 are numerous and found to be associated with a diversity of neoplasms as well as constitutional disorders. Chromosome 11 in bands q23-q24 is similarly involved in several types of tumors as well as in a recurri...

Mature B-cell acute lymphoblastic leukemia (ALL) or Burkitt-type ALL is a rare entity and can be defined as the leukemic manifestation of Burkitt lymphoma (BL).1 BL is a highly aggressive B-cell malignancy and can be endemic, sporadic, or associated with immunodeficiency.2,3 Sporadic BL accounts for 1-2% of all adult lymphoma in Western Europe and the United States.2 Mature B-cell ALL is charac...

Cytogenetic abnormalities seen at presentation of acute lymphoblastic leukemia or lymphoblastic lymphoma (ALL/ LBL) are associated with distinct clinical and hematologic disease entities. T-ALL/LBL are morphologically indistinguishable from those of B-ALL/LBL. An abnormal kariotype is found in 50-70% of cases of T-ALL/LBL. We present a 35-year old male patient with T-ALL/LBL and t(8;14)(q24;q11...

Levofloxacin was investigated against viridans group streptococci in vitro and in rats with experimental aortic endocarditis. The MIC(90)s of levofloxacin and ciprofloxacin for 20 independent isolates of such bacteria were 1 and 8 mg/L, respectively. Rats were infected with two types of organism: either fully susceptible to levofloxacin MIC < or = 0.5 mg/L) or borderline susceptible (MIC 1-2 mg...

Objective: To develop a Verapamil hydrochloride controlled release gastro-retentive (CRGR) tablet for once-daily dosing using the response surface Box-Behnken Design (BBD) approach improvement of bioavailability and reduction in frequency to overcome issues related conventional formulation. Methods: For optimization, 33Box-Behnken design was used. The independent variables were selected, amount...

Forty humane society cats with suspected bacterial upper respiratory infections (URIs) were studied in order to compare amoxycillin and pradofloxacin for treatment of rhinitis and describe common pathogens. Nasal discharges were collected prior to random placement into one of three treatment groups. Cats failing to initially respond were crossed to the alternate drug. Drug toxicity was not note...

Homeotic or homeobox genes represent selector genes involved in the genetic control of development and organization of the body plan. They are characterized by a common highly conserved sequence stretch of approximately 60 amino acids, the homeodomain (McGinnis et al., 1984). In vertebrates, four homeobox gene clusters (HOXA, HOXB, HOXC, and HOXD) have been described (Scott, 1992). In each clus...

DH Burkitt lymphoma and Burkitt leukemia (also called mature B-cell acute lymphocytic leukemia [ALL]) have identical cytogenetic aberrations, surface markers, and molecular genetics. The clinical manifestations of Burkitt lymphoma resemble more of high grade malignant lymphomas, whereas B-cell ALL is similar to other subtypes of ALL. Additionally, there is a substantial difference in epidemiolo...