Chronic intermittent hypoxia, a characteristic of obstructive sleep apnea (OSA), is associated with the progression of simple hepatic steatosis to necroinflammatory hepatitis. We determined whether inhibition of a hypoxia-induced signaling pathway could attenuate hypoxia-exacerbated lipoapoptosis in human hepatocytes. The human hepatocellular carcinoma cell line (HepG2) was used in this study. ...

The approach using pyrrolidine enamine as substrate has been studied for this synthesis, and an important catalyst structural feature has been developed. After survey of pyrrolidine-based Brønsted acid catalyst, tetrazole catalyst (3f) was found to be optimal in synthesis of aminooxy carbonyl compounds in high yields, with complete enantioselectivity not only for aldehydes but also for ketones.

This study is aimed at investigating the effect of specific modulators transcription factors NF-κB and Nrf2 on indicators oxidative-nitrosative stress in periodontal soft tissues early post-traumatic period after experimental model moderate traumatic brain injury (TBI). The experiment was conducted 20 white male Wistar rats weighing 180-220 g, divided into 4 groups: 1st (pseudo-traumatized anim...

nitration of potassium sulphamate was carried out using a mixture of sulphuric and nitric acid at -30 °c. the reaction time was optimized at the mole ratio of sulphuric to nitric acid of (1:3.5). the difference in product yield by changing the potassium to ammonium sulphamate was studied throughly. it was found that both the yield and purity of the product is better starting with potassium sulp...

introduction: polyclonal antibodies are required to be affinity purified. improved purification methods of polyclonal antibody provide an opportunity to pick the most purified immunoglobulins as a primary or secondary antibody in immunoassays that are included in many vaccine studies. two common techniques for purifying proteins is salt precipitation and chromatography purification. our work fo...

plant biomass harvested after heavy-metal phytoremediation must be considered as a hazardous waste that should be contained or treated appropriately before disposal or reuse. this study provides an evaluation of extractants for the removal of lead from abutilon theophrastus biomass. the research was carried out a leaching study to determine the lead-extraction efficiency of the different leacha...

It has been pointed out (1) that, in terms of modern acid-base chemistry, the defects reponsible for the acidosis of renal disease could be: 1) impaired renal excretion of acid in the form of ammonium and titratable acidity, 2) loss of bicarbonate (alkali) in the urine due to a failure of renal bicarbonate conservation or 3) a combination of these two defects. The two main components of urine r...