Evidence for an error-free DNA damage tolerance process in eukaryotes (also called postreplication repair) has existed for more than two decades, but its underlying mechanism, although known to be different from that in prokaryotes, has remained elusive. We have investigated this mechanism in Saccharomyces cerevisiae, in which it is the major component of the RAD6/RAD18 pathway, by transforming...

A new series of thienothiadiazolopyrimidinone 4 was prepared via the reaction of hydrazonoyl chlorides 2 with 2amino-tetrahydrobenzo[b]thiophene-3-carboxylic acid 1 followed by cyclization with 1,1`-carbonyldiimidazole. Furthermore, benzothienothiadiazolo pyrimidinone derivatives 11a-c were prepared. The structure of the newly synthesized compounds were established on the basis of spectral data...

High Internal Phase Emulsion hydrogels are prepared from waterborne poly(N-isopropylacrylamide) nanogel dispersions which are non-covalently crosslinked through 2-ureido-4[1H] pyrimidinone (UPy) quadruple hydrogen bond groups. The reversible UPy crosslinks allow for the HIPE-hydrogels to be molded into objects which are thermo-responsive in nature.

In the mol-ecule of the title compound, C(18)H(22)N(2)O(3), the dihydro-pyrimidinone ring adopts an envelope conformation. The dihedral angle between the phenyl ring and the mean plane through the enamine fragment is 86.04 (7)°. The mol-ecular conformation is stabilized by an intra-molecular C-H⋯O hydrogen bond. In the crystal, inter-molecular N-H⋯O hydrogen bonds link pairs of mol-ecules into ...