Enzyme induction in Escherichia coli is stimulated by certain 5-amino-2,4-bis(substitutedamino)pyrimidines (Kunkee, 1960a). Other 2,4diaminopyrimidines have been reported to be antagonists of folic acid (Hitchings et al., 1952; Doctor, 1956). Since there are indications that the stimulation of enzyme induction involves nucleic acid metabolism (Kunkee, 1960b) and since folic acid is involved in ...

Thiophene substituted chalcones (1a-e) were cyclised with thiourea in presence of potassium hydroxide to get 4-substituted-6-(thiophen-2-yl)pyrimidine-2-thiols (2a-e) which were then stirred with methyl iodide to obtain 4-substituted-2-(methylsulfanyl)-6-(thiophen-2-yl)pyrimidines (3a-e). Compounds (3a-e) were refluxed with different N-methylpiperazine and N-phenylpiperazine to afford 4-substit...

The requirement of many Brucella abortus strains for a PCO2 of approximately 0.03 atmosphere for growth seems to differ both quantitatively and qualitatively from the C02 requirement of other heterotrophic organisms. In some microorganisms, C02 can be replaced by certain tricarboxylic acids (Lwoff and Monod, 1946; Ajl and Werkman, 1948), amino acids (Lyman et al., 1947; Abelson et al., 1952a, b...

A two-year-old boy with a malignant tumor of the brain (medulloblastoma) excreted large amounts of thymine and uracil in his urine. The excretion was related to progress and regress of the disease, and reached a maximum of 3.0 mol of thymine per mole of creatinine and 2.6 mol of uracil per mole of creatinine. The excretion by 20 apparently normal children was less than 0.01 mol/mol of creatinin...

Since alcohols are accessible from indigestible biomass (lignocellulose), the development of novel preferentially catalytic reactions in which alcohols are converted into important classes of fine chemicals is a central topic of sustainable synthesis. Multicomponent reactions are especially attractive in organic chemistry as they allow the synthesis of large libraries of diversely functionalize...

Sequence analysis of 5'-[32P] labeled tRNA and eukaryotic mRNA using an adaptation of a method recently described by Donis-Keller, Maxam and Gilbert for mapping guanines, adenines and pyrimidines from the 5'-end of an RNA is described. In addition, a technique utilizing two-dimensional polyacrylamide gel electrophoresis for identification of pyrimidines within a sequence is described. 5'-[32P] ...

We have previously reported on the tumor inhibitory properties of 5-fluorouracil and 5-fluoroorotic acid (3, 4), prepared by Duschinsky et al. (5), and on the initial clinical trials of 5fluorouracil with patients with far advanced solid tumors (6). The metabolism of 5-fluorouracil and 5-fluororotic acid has been studied, data on excretion and tissue distribution in mice and man have been repor...