In the title compound, C(14)H(13)N(5), the pyrazole ring is disordered over two orientations in a 0.571 (10):0.429 (10) ratio and the dihedral angle between the pyridazine ring and the benzene ring is 28.07 (10)°. In the crystal, pairs of N-H⋯N and C-H⋯N hydrogen bonds link the mol-ecules into dimers, with the aid of a crystallographic twofold axis. The packing is consolidated by further C-H⋯N ...

Donor molecules of the D-π-A-π-D type structure are often used for applications in organic photovoltaics. In this communication, bromination 4,7-di(thiophen-2-yl)-[1,2,5]thiadiazolo[3,4-d]pyridazine followed by Suzuki cross-coupling with carbazoleboronic acid gave 4,7-bis( 5-(9-hexyl-9H-carbazol-3-yl)thiophen-2-yl)-[1,2,5]thiadiazolo[3,4-d]pyridazine. The newly synthesized compounds was establi...

As part of our ongoing scaffold-hopping work on an antikinetoplastid 3-nitroimidazo[1,2-a]pyridine scaffold, we explored 3-nitroimidazo[1,2-b]pyridazine as a potential new series. Using conditions previously described by lab, obtained 6-chloro-3-nitro-2-[(phenylsulfonyl)methyl]imidazo[1,2-b]pyridazine with 54% yield. In vitro activity this compound was evaluated against both the promastigote fo...

Orbital interaction is fundamentally important in understanding molecular structure, reaction mechanism, and chemical reactivity. The extent of orbital interaction is, however, hardly known quantitatively, and resulting molecular properties have often been inferred from general conceptual rules of thumb which cannot be validated. One way to find out the extent of orbital interactions is to indu...

The reaction of [Ir(IMes)(COD)Cl], [IMes 1⁄4 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene, COD 1⁄4 1,5cyclooctadiene] with pyridazine (pdz) and phthalazine (phth) results in the formation of [Ir(COD)(IMes)(pdz)]Cl and [Ir(COD)(IMes)(phth)]Cl. These two complexes are shown by nuclear magnetic resonance (NMR) studies to undergo a haptotropic shift which interchanges pairs of protons within th...

In an attempt to design ligands which require both a high iron(III) affinity and a low iron(II) affinity, the 3-hydroxypyridin-4-one structure has been modified to introduce an additional nitrogen atom in the pyridine ring to form a pyridazine. The target molecules were synthesized from a chlorine-substituted pyridazine using step-by-step methoxylations. A total of six 3- and 5-hydroxypyridazin...

The synthesis of novel pyrazole derivatives and investigations of their chemical and biological behavior have gained more importance in recent decades for biological, medicinal, and agricultural reasons. Concerning the attempt to synthesize some novel pyrazole and fused pyrazole derivatives from 4-benzoyl5-phenyl-2,3-furandione 1 and various hydrazines or hydrazones, the synthesis of 4-benzoyl-...

The title compound, [PdCl2(C4H4N2)2], contains two crystallographically unique complexes; the Pd(II) atom lies on an inversion center in both cases. The two pyridazine units bonded to the Pd(II) atom are thus coplanar although dihedral angles within each complex are different. In one complex, the angle between the ring plane and Pd-Cl bond is almost perpendicular [89.4 (1)°], while the other is...

The asymmetric unit of the title compound, [Zn(NCSe)(2)(C(4)H(4)N(2))(2)], consists of one Zn(II) cation, located on a twofold rotation axis, one seleno-cyanate anion and one pyridazine ligand in general positions. The Zn(II) atom is coordinated by two N-atoms of two pyridazine ligands and two terminal N-bonded seleno-cyanate anions within a slightly distorted tetra-hedral coordination environm...