نتایج جستجو برای: pyrazolone

تعداد نتایج: 399  

Journal: :The Journal of Experimental Medicine 2005
Hyunsil Han Alexander Stessin Julia Roberts Kenneth Hess Narinder Gautam Margarita Kamenetsky Olivia Lou Edward Hyde Noah Nathan William A. Muller Jochen Buck Lonny R. Levin Carl Nathan

Through chemical screening, we identified a pyrazolone that reversibly blocked the activation of phagocyte oxidase (phox) in human neutrophils in response to tumor necrosis factor (TNF) or formylated peptide. The pyrazolone spared activation of phox by phorbol ester or bacteria, bacterial killing, TNF-induced granule exocytosis and phox assembly, and endothelial transmigration. We traced the py...

2012
Zhao Zhang Xingqiang Lü Shunsheng Zhao Xiangrong Liu

The mol-ecule of the title compound, C(27)H(22)N(4)O, assumes a non-planar conformation in which the pyrazolone ring forms dihedral angles of 12.73 (11), 65.17 (6) and 49.82 (6)°, respectively, with the two benzene rings and the naphthalene ring system. In the crystal, pairs of mol-ecules are linked by inter-molecular N-H⋯N hydrogen bonds, forming dimers. The secondary amino group is involved i...

Journal: :Journal of The Chilean Chemical Society 2021

Pyrazolone is a five-membered lactam ring containing two Nitrogens and one ketonic group in its structure. Numerous pyrazolone derivatives were exhibited with diverse biological, pharmacological, chemical applications. When pyrazolones discovered, they only known as NSAIDs but recent times play versatile role several complications like cerebral ischemia, cardiovascular diseases, antibacterial, ...

Journal: :iranian journal of mathematical chemistry 2013
h. tavakol h. mohammadi s. a. aslanzadeh

in the present work, dft calculations are employed to obtain the optimized structures of 4-acyl pyrazolone tautomers (19 tautomers) using b3lyp/6-311++g** calculations. inaddition, molecular parameters, ir frequencies and relative energies are extracted for alltautomers. the existence of aromatic ring, keto tautomer (versus enol tautomer), n-h bond(versus c-h bond) and c=n double bond (versus n...

Journal: :The Journal of the Society of Chemical Industry, Japan 1959

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