BACKGROUND Administration of topical rapamycin (RPM) suppresses the regeneration and revascularization of photocoagulated blood vessels induced by pulsed dye laser (PDL). OBJECTIVE To systematically elucidate the molecular pathophysiology of the inhibition of PDL-induced angiogenesis by topical RPM in a rodent model. METHODS The mRNA expression profiles of 86 angiogenic genes and phosphoryl...

Actas Dermosifiliogr. 2008;99:493-501 494 application of 1% atropine has produced a response in some patients,8 but not in others.5,7 Other treatments include the use of CO2 lasers or pulsed dye laser,9 destruction using electrodesiccation with a fine needle electrode, and injections of botulinum toxin.10 In cases where there was an underlying disorder such as hyperthyroidism, resolution of the...

BACKGROUND AND OBJECTIVES Infantile hemangiomas are the most common benign tumor in children. They have 3 phases of development: a proliferative phase, an involuting phase, and involution. Although active treatment is often not required, it is necessary in some cases. Of the possible treatments for hemangiomas, lasers have been shown to be effective in all phases of development. We report our e...

Psoriasis can involve the skin, joints, and nails, either alone or in combination. Psoriasis of the nails can involve both the nail bed and nail matrix. The treatment of nail psoriasis largely depends on the severity of symptoms. The pulsed dye laser (PDL) recently has demonstrated efficacy in treating resistant plaque-type psoriasis and has been suggested as an alternative to conventional ther...

A simple model is presented as an aid in understanding, first, the relative noise performance and, second, the noise reduction achievable by referencing, in different experimental approaches to single shot broadband coherent anti-Stokes Raman scattering (CARS). Qualitative agreement is obtained with previous experimental investigations of CARS noise. The broadband dye laser radiation is describ...

Different rotational CARS techniques have been evaluated in terms of single-shot temperature accuracy and signal intensity in room temperature nitrogen and in flames. The different techniques include both dual broadband techniques, using one or two broadband dye lasers, and conventional rotational CARS with different dye lasers. These techniques are also compared with vibrational CARS concernin...

In vivo photoacoustic (PA) and fluorescence flow cytometry were previously applied separately using pulsed and continuous wave lasers respectively, and positive contrast detection mode only. This paper introduces a real-time integration of both techniques with positive and negative contrast modes using only pulsed lasers. Various applications of this new tool are summarized, including detection...