OBJECTIVES Amoxicillin and clarithromycin have been proven to be effective in the treatment of community-acquired pneumonia. This study investigated the in vivo bactericidal efficacy of a novel, pulsatile dosing strategy for amoxicillin and clarithromycin, when used as monotherapy and combination therapy. METHODS A neutropenic murine pneumonia model was used to assess the bactericidal activit...

The transition between puberty and adulthood is accompanied by a slowing in linear growth. Although GH is a key factor that drives somatic development into adulthood, early adulthood coincides with a reduction in circulating levels of GH. To this extent, a pathological decline in postpubertal GH secretion is detrimental to attainment of peak lean muscle mass and bone mass and promotes adiposity...

Pulsatile scrotal masses are extremely rare. We report the first case of pulsatile and painful scrotal mass that had an arterial collateral circulation, equivalent to an arterioarterial shunt, feeding an excluded internal iliac artery aneurysm after aortobifemoral bypass surgery.

many diseases are related to cerebrospinal .uid (csf) hydrodynamics. therefore, understanding the hydrodynamics of csf .ow and intracranial pressure is helpful for obtaining deeper knowledge of pathological processes and providing better treatments. furthermore, engineering a reliable computational method is promising approach for fabricating in vitro models which is essential for inventing gen...

Heart failure has become a major health problem worldwide with a substantial financial burden mainly from hospitalization due to acute heart failure syndrome (AHFS). A considerable number of patients hospitalized for the treatment of AHFS experience significant worsening of renal function, which is now recognized as type 1 cardiorenal syndrome (CRS) and is associated with worse outcomes. Curren...

OBJECTIVE To evaluate the performance of the various speech processing strategies supported by the Clarion S-Series implant processor. DESIGN Five different speech-processing strategies [the Continuous Interleaved Sampler (CIS), the Simultaneous Analog Stimulation (SAS), the Paired Pulsatile Sampler (PPS), the Quadruple Pulsatile Sampler (QPS) and the hybrid (HYB) strategies] were implemented...

PURPOSE OF REVIEW Identification of the underlying cause of pulsatile tinnitus is important for treatment decision making and for prognosis estimation. For this, an adequate diagnostic imaging strategy is crucial. RECENT FINDINGS Both CT and MRI can be useful, and in general, these modalities provide complementary diagnostic information. The scanning protocol can be optimized based on the est...

The presented software-based approach enables precise pulsatile flow generation in microfluidics without any hardware modifications to study time-dependent flows using commercial pressure controllers.

Abstract Background Pulsatile flow has been proved to protect vital organ function and microcirculation during extracorporeal membrane oxygenation (ECMO). Studies revealed that pulsatile shear stress plays a role in the microcirculatory integrity. The objective of this study was investigate how pulsatility affects wall ECMO. Methods Using i-Cor system, we compared effects pulstile or non-pulsat...

Effective arterial elastance (E(A)) was proposed as a lumped parameter that incorporates pulsatile and resistive afterload and is increasingly being used in clinical studies. Theoretical modeling studies suggest that E(A) is minimally affected by pulsatile load, but little human data are available. We assessed the relationship between E(A) and arterial load determined noninvasively from central...