STUDY OBJECTIVES To validate lung diffusing capacity for nitric oxide (DLNO) as an index of conductance of the alveolar-capillary membrane during exercise, we compared DLNO to lung diffusing capacity for carbon monoxide (DLCO) and pulmonary membrane diffusing capacity for carbon monoxide (DMCO), and compared pulmonary capillary blood volume (Vc) calculated by two methods. SETTING AND PARTICIP...

BACKGROUND An increase in pulmonary capillary blood volume secondary to angiogenesis has been described in Kaposi's sarcoma. The value of the pulmonary capillary blood volume as an early marker of pulmonary Kaposi's sarcoma was evaluated. METHODS In a prospective study 45 HIV positive patients (nine asymptomatic for Kaposi's sarcoma, 29 with cutaneous or mucocutaneous Kaposi's sarcoma, and se...

We aimed to characterise the association of pulmonary hypertension due to hypoventilation and exercise capacity, and the haemodynamic and functional changes under noninvasive ventilation. A retrospective analysis was carried out to assess haemodynamics and functional capacity in 18 patients with daytime pulmonary hypertension, due to hypoventilation, at baseline and after 3 months of noninvasiv...

Patients with chronic thromboembolic pulmonary hypertension (CTEPH), despite successful pulmonary endarterectomy (PEA), can continue to suffer from a limitation in exercise capacity. The objective of this study was to assess whether pulmonary arterial compliance is a predictor of exercise capacity after PEA. Right heart haemodynamics, treadmill incremental exercise test, spirometry, carbon mono...

Word Count: 200 Text Word Count: 2697 Number of Tables and Figures: 6 Running Title; Pulmonary Function in Smokers with Diabetes Mellitus Page 1 of 22 Diabetes Care Diabetes Care Publish Ahead of Print, published online September 11, 2013 ABSTRACT OBJECTIVE: Diabetes mellitus damages major organ systems through disrupted glycemic control and increased inflammation. The effects of diabetes on th...

[Purpose] The purpose of this study was to identify changes in pulmonary function and pulmonary strength according to time of day. [Subjects and Methods] The subjects were 20 healthy adults who had no cardiopulmonary-related diseases. Pulmonary function and pulmonary strength tests were performed on the same subjects at 9:00 am, 1:00 pm, and 5:00 pm. The pulmonary function tests included forced...

Steady state measurements of the diffusing capacity of the lung are made at operational lung volume, whereas measurements by the breath-holding method are customarily made at full inspiration. The effect of lung inflation on diffusing capacity must be taken into account before the steady state and breath-holding methods can be validly compared. At rest the single breath diffusing capacity of th...

In nine patients with large pleural effusions, we studied the changes in pulmonary mechanics and gas exchange that occurred in the first three hours following removal of 600 to 1,800 ml of fluid by thoracocentesis. There was a small but significant increase in the functional residual capacity and total lung capacity but no change in residual volume and vital capacity. Calculated pulmonary shunt...

Previous studies in pulmonary sarcoidosis have demonstrated that impairment of the diffusing capacity is the most frequent abnormality of pulmonary function in this condition (Marshall, Smellie, Baylis, Hoyle, and Bates, 1958). The work of Roughton and Forster (1957) showed that the diffusing capacity could be divided into two components: one involves the transfer of oxygen through the alveolar...

The transfer factor of the lung for carbon monoxide (TL,CO) is decreased in patients with pulmonary hypertension. The pulmonary membrane diffusion capacity (Dm) and pulmonary capillary blood volume (Vc), were studied to establish: 1) the relative contribution of the components of the transfer factor to the decrease in TL,CO; 2) whether differences exist between primary pulmonary hypertension (P...