Haematological and rheological (plasma and serum viscosity, whole blood viscosity, and erythrocyte filterability) factors were studied in 31 age-sex matched pairs of patients with sickle cell haemoglobin C disease with and without proliferative sickle retinopathy (PSR). Patients with PSR had significantly higher mean cell haemoglobin and lower Hb F levels on average than the matched controls, b...

Predictive state representations (PSRs) represent the state of a dynamical system as a set of predictions about future events. The parameters of a PSR model consist of several matrices and vectors, but not all values for those parameters result in valid PSR models. Our work starts with a general definition of what it means to be a valid PSR model and derives necessary and sufficient constraints...

Purpose Retinal vascular occlusions in sickle cell anemia patients cause tissue ischemia and the release of angiogenic mediators that promote the development of retinal neovascularization, initiating proliferative sickle retinopathy (PSR). Laser photocoagulation (LPC) has emerged as the most common treatment for PSR. Nonetheless, only two randomized controlled clinical trials have evaluated the...

We report circumstantial evidence for the first detection of pulsed high-energy γ-ray emission from a millisecond pulsar, PSR J0218+4232, using data collected with the Energetic Gamma Ray Experiment (EGRET) on board the Compton Gamma Ray Observatory (CGRO). The EGRET source 3EG J0222+4253 is shown to be spatially consistent with PSR J0218+4232 for the energy range 100–300 MeV. Above 1 GeV the n...

Graph languages defined by hyperedge replacement grammars can be NP-complete. We study predictive shift-reduce (PSR) parsing for a subclass of these grammars, which generalizes the concepts of SLR(1) string parsing to graphs. PSR parsers run in linear space and time. In comparison to the predictive top-down (PTD) parsers recently developed by the authors, PSR parsing is more efficient and more ...

A widespread phenomenon in nature is sex ratio distortion of arthropod populations caused by microbial and genetic parasites. Currently little is known about how these agents alter host developmental processes to favor one sex or the other. The paternal sex ratio (PSR) chromosome is a nonessential, paternally transmitted centric fragment that segregates in natural populations of the jewel wasp,...

The present Serviceability Rating (PSR) is one of the major criteria in selecting road for rehabilitation. In this paper, statistically realistic models for are developed PSR and free speed correlation on uninterrupted flow facilities. Then, the previously developed relations between free speed and capacity are used to determine the effect of pavement condition on flow capacity. Two nearly iden...

Candida albicans is the most common human yeast pathogen which causes mucosal infections and invasive fungal diseases. Early detection of this pathogen is needed to guide preventative and therapeutic treatment. The aim of this study was to establish a polymerase spiral reaction (PSR) assay that rapidly and accurately detects C. albicans and to assess the clinical applicability of PSR-based diag...

The recent success of therapies directly targeting the angiogenic mediator, vascular endothelial growth factor (VEGF), for the treatment of proliferative diabetic retinopathy has encouraged clinicians to extend the use of anti-VEGF therapies for the treatment of another ischemic retinal vascular disease, proliferative sickle cell retinopathy (PSR), the most common cause of irreversible blindnes...

We have studied the variability of PSR J0529−6652, a radio pulsar in the Large Magellanic Cloud (LMC), using observations conducted at 1390 MHz with the Parkes 64 m telescope. PSR J0529−6652 is detectable as a single pulse emitter, with amplitudes that classify the pulses as giant pulses. This makes PSR J0529−6652 the second known giant pulse emitter in the LMC, after PSR B0540−69. The fraction...