نتایج جستجو برای: psoriasis area
تعداد نتایج: 600519 فیلتر نتایج به سال:
206 2. Day C, McCollum EV. Effect of acute dietary zinc deficiency in rat. Proc Exp Biol Med 1940;45:282-7. 3. Saxena N, Sharma RP, Singh VS. A study of serum zinc and copper levels in psoriasis. Indian J Dermatol Venereol Leprol 1990;56:216-8. 4. McMillan C, Rowe D. Plasma zinc in psoriasis: Relationship to surface area involvement. Br J Dermatol 1983;108:301-5. 5. Portnoy K, Molokhia M. Zinc ...
Interleukin-18 is a cytokine with a possible role in the pathogenesis of psoriasis. We examined subpopulations of peripheral blood lymphocytes and their expression of activation markers and correlated this with plasma levels of IL-18 and clinical disease severity in patients with psoriasis. We included 12 patients with psoriasis who had a PASI score from 15 to 48 and compared them to controls. ...
OBJECTIVE To evaluate the safety and efficacy of long-term treatment of psoriasis with etanercept, 50 mg twice weekly. DESIGN, SETTING, AND PATIENTS A phase 3, randomized, double-blind trial with an open-label extension. A total of 618 adult patients with moderate to severe plaque psoriasis were studied at 39 medical centers in the United States and Canada from May 23, 2003, through June 22, ...
Interleukin 16 (IL-16) has been described as a significant cytokine involved in the recruitment of CD4+ cells during inflammation; however, its potential role in psoriasis has not been defined. Our aim was to investigate the IL-16 serum levels and IL-16 mRNA skin expression in psoriasis patients in correlation with disease severity and mRNA skin expression for CD4. Moreover, the IL-16 skin loca...
The definitions of psoriasis severity and clinically significant improvement in psoriasis are used to classify treatments, obtain Food and Drug Administration approval, and determine product labeling and reimbursement. The Medical Advisory Board of the National Psoriasis Foundation has addressed these issues because of their importance in the clinical trials that are conducted to gain FDA appro...
Increasing epidemiological evidence suggests independent associations between psoriasis and cardiovascular and metabolic disease. Our objective was to test the hypothesis that directly assessed psoriasis severity relates to the prevalence of metabolic syndrome and its components. A population-based, cross-sectional study was undertaken using computerized medical records from the Health Improvem...
Background & Objective: Psoriasis is a chronic and relapsing disease with a prevalence of 2%. Since it is a chronic and non-fatal skin disease, its impact on quality of life in patients is underestimated compared to other diseases. This study points out to the importance of the quality of life in these patients and their correlation with disease severity. Materials & Methods: Quality of life...
Psoriasis is a common chronic persistent inflammatory skin disorder distinguished by hyperproliferation and reduced differentiation of keratinocytes. 2-3% of the population is affected by this inflammatory skin disease. Biomarkers could be relevant for distinction between the different clinical variants of the disease, for assessment of disease activity and severity, and for prediction of the o...
Psoriasis is a chronic, recurrent, inflammatory, and hyperproliferative disease. Recently there have been studies regarding increases in the levels of NO in inflammatory dermatoses including psoriasis. In this study, 22 patients with psoriasis were scored with PASI (psoriasis area and severity index) and the levels of serum nitrite-nitrate were evaluated before and after therapy with methotrexa...
Using a strictly defined grading system to eliminate subjective assessment of mucosal architecture, the jejunal mucosa from cases of extensive psoriasis has been shown to be significantly different from that of normal controls obtained both in life and at postmortem examination. The same changes, however, are shown to occur in patients who are ill and losing weight for reasons other than psoria...
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