Psoralea corylifolia L. (PC) is a traditional Chinese herb used to treat yang deficiency of the spleen and kidney in pediatric disease. Recent studies have shown its liver protection and anti-oxidative effects. The aim of this study was to explore the effect and mechanism of PC on nonalcoholic steatohepatitis in juvenile mice. The juvenile mouse model of nonalcoholic fatty liver disease/nonalco...

The current study focuses on phytochemical screening of Psoralea corylifolia and Emblica officinalis leaf extracts in methanol solvent. antibacterial compounds found both plants were investigated using studies. contained flavonoids, terpenoids, tannins, alkaloids, saponins, phenolic chemicals, according to preliminary screening. solvent systems toluene: ethyl acetate: (24:5:2) chloroform: aceti...

Abstract Plants are considered as a source of medicine to treat skin-related disorders since decades. Seeds Psoralea corylifolia were used thousands years ago for re-pigmentation in vitiligo patients especially South Asia. It is well-known fact that melanocytes, which the specialized cells skin causes through series chemical and enzymatic reactions, mainly due copper containing enzyme tyrosinas...

Mulberry silkworm, Bombyx mori L, most valued for silk and other medicinal products is prone to various biotic stresses among which the disease caused by Nuclear Polyhedrosis Virus (BmNPV) is most serious as it occurs throughout the year causing losses to the tune of 30-40 per cent. Studies conducted on eco friendly management of the disease using botanicals revealed that 800 ppm hexane leaf ex...

BACKGROUND Psoralea Fructus (PF), the dried and ripe fruit of Psoralea corylifolia exhibits an anti-cancer activity. However, the molecular mechanisms by which PF inhibits the proliferation of cancer cells have not been elucidated in detail. Cyclin D1 and CDK4 are important regulatory proteins in cell growth and are overexpressed in many cancer cells. In this study, we investigated the molecula...

The case of a 64 year old female patient is presented who has treated herself for 9 months with various Indian Ayurvedic herbal products for her vitiligo and experienced a causally related severe hepatotoxicity (ALT, 601 U/L; AST, 663 U/L; Bilirubin, 5.0 mg/dL). After discontinuation, a rapid improvement was observed. Causality assessment with the updated CIOMS (Council for International Organi...

The circadian clock regulates many aspects of (patho)physiology in the central nervous system and in the peripheral tissues. RAR-related orphan receptor α (RORα), an orphan nuclear receptor, is involved in circadian rhythm regulation, including regulation of cardiovascular function. Bavachalcone, a prenylchalcone, is a major bioactive chalcone isolated from Psoralea corylifolia. This natural in...

In the present investigation antimicrobial activity of six different plant essential oils i.e., citrus (Citrus lemon), olive (Olea europaea), ajwain (Trachiyspirum ammi), almond (Amygdalus communis), Bavchi (Psoralea corylifolia) and neem (Azadirachta indica) oils have been evaluated. After bioassays, most of the essential oils were found susceptible to both Gram-positive bacteria such as Lacto...