After a hiatus of some 40 years, clinical research has resumed on the use of classic hallucinogens to treat addiction. Following completion of a small open-label feasibility study, we are currently conducting a double-blind placebo-controlled clinical trial of psilocybin-assisted treatment of alcohol use disorder. Although treatment effects cannot be analyzed until the study is complete, descri...

Psilocybe semilanceata, Hallucinogenic Mushrooms, Psilocybin, Baeocystin, HPLC The content of tryptamine derivatives in Psilocybe semilanceata, a popular hallucinogenic mushroom, was measured by high-performance liquid chromatography. Most of the 52 samples have been collected at several localities in Switzerland during a 1—5 year period. The content of psilocybin and baeocystin varied in the r...

Obsessive Compulsive Disorder (OCD) is a psychiatric disorder with considerable morbidity and mortality. This condition disables many individuals and is often refractory to treatment. Research suggests that serotonin plays a role in OCD symptom reduction. We present a case of an individual who successfully used psilocybin, a serotonergic agent, to reduce the core symptoms of OCD for several yea...

Background Recent survey data indicate that some people report long-term improvement in color vision deficiency (CVD), also known as blindness, following use of psychedelics such lysergic acid diethylamide (LSD) and psilocybin. However, there are no objective reported the medical literature quantifying degree or duration CVD associated with psychedelic use. Case presentation Here we present cas...

Background and objectives: Considering the increasing prevalence of depression, many studies are launched to investigate new antidepressant treatments. The present research has shown how psilocybin as an active compound of Psilocybe cubensis (Earle) Singer extract (PCE) can change the parameters related to depression and anxiety in animal models. Both ...

Growing research on potential therapeutic applications of highly restricted Schedule I hallucinogens, including the ‘classic psychedelic’ psilocybin, and entactogen 3,4-Methylenedioxymethamphet...