Tedizolid phosphate is a novel oxazolidinone prodrug whose active moiety, tedizolid, has improved potency against Gram-positive pathogens and pharmacokinetics, allowing once-daily administration. Given linezolid warnings for drug-drug and drug-food interactions mediated by monoamine oxidase (MAO) inhibition, including sporadic serotonergic toxicity, these studies evaluated tedizolid for potenti...

A 58-year-old man with psychosis had been unsuccessfully treated with multiple trials of conventional and atypical antipsychotics, antidepressants, mood stabilizers, and anxiolytics.1 His psychiatric status remained unstable, and he was hospitalized and started on clozapine (Clozaril). Results of laboratory analyses (e.g., white blood cells, absolute neutrophil counts) remained within normal li...

AIM The aim of this study was to explore factors affecting efficacy of treatment of common cold symptoms with an over-the-counter ibuprofen/pseudoephedrine combination product. METHODS Data from an anonymous survey among 1770 pharmacy customers purchasing the combination product for treatment of own common cold symptoms underwent post-hoc descriptive analysis. Scores of symptoms typically res...

Chloroephedrine is an intermediate and possible contaminant formed when methamphetamine is manufactured using ephedrine or pseudoephedrine as precursors. The purpose of this study was to determine whether this contaminant has biological activity and might contribute to methamphetamine-induced cardiovascular toxicity. In conscious rats, the (-) and (+) isomers of chloroephedrine (0.1 and 1.0 mg/...

Volume 22, Issue 7 April 2007 1 During the peak of cough and cold season millions, of Americans find themselves searching through the cold medicine section of the neighborhood store in an attempt to relieve nasal stuffiness and sinus pressure. Until recently, the choice included with the ingredient pseudoephedrine found in over 700 cough and cold remedies. Pseudoephedrine (Sudafed ® ) , phenylp...

BACKGROUND AND PURPOSE Phenylpropanolamine (PPA) and pseudoephedrine are sympathomimetics contained in over-the-counter cold preparations. A case-control study linked PPA use with hemorrhagic stroke in women. Twenty-two patients with stroke associated with use of these drugs are described. METHODS In a consecutive stroke registry since 1988, 22 patients had stroke associated with over-the-cou...

In  the  current  study,  a  new  technique  was  developed  for  quantification  and  qualification  of pseudoephedrine hydrochloride (PSE) in a real sample, which was based on electrochemical sensors and  molecular  imprinted  polymer  (MIP).  The  carbon  paste  electrode  (CPE)  was  modified  and optimized by a different ratio of MIP. MIP/CPE was used as the extraction and working electrod...

OBJECTIVES Restrictions on retail purchases of pseudoephedrine are one regulatory approach to reduce the social costs of methamphetamine production and use, but may impose costs on legitimate users of nasal decongestants. This is the first study to evaluate the costs of restricting access to medications on consumer welfare. Our objective was to measure the inconvenience cost consumers place on ...

Title of Thesis: BIOACTIVITY OF EPHEDRA: INTEGRATING CYTOTOXICITY ASSESSMENT WITH REAL-TIME BIOSENSING Kazuko Fukushima, Master of Science, 2004 Thesis Directed By: Dr. Y. Martin Lo, Department of Nutrition and Food Science Ephedrine-type alkaloids (ETA) are major active ingredients of Ephedra, a traditional Chinese medicinal herb used to treat asthma and nasal congestion. Until recently, large...

Complete discrimination of ephedrine and pseudoephedrine, both in solution and in the solid state, was achieved with a phosphonate cavitand receptor. The molecular origin of the epimer discrimination was revealed by the crystal structure of the respective complexes.