Porcine reproductive and respiratory syndrome (PRRS) is caused by PRRS virus (PRRSV), which infects primarily the respiratory tract of pigs. Thus intranasal (IN) delivery of a potent vaccine-adjuvant formulation is promising. In this study, PRRS-MLV (VR2332) was coadministered ± an adjuvant Mycobacterium vaccae whole cell lysate or CpG ODN through intramuscular (IM) or IN route as a mist, and c...

One hundred Hampshire x Duroc cross-bred pigs (HD) and 100 NE Index line (I) pigs were infected with porcine reproductive and respiratory syndrome (PRRS) virus and evaluated for resistance/susceptibility. Controls (100/line) were uninfected littermates to the infected pigs. Viremia, change in weight (WTdelta), and rectal temperature at 0, 4, 7, and 14 d postinfection were recorded. Lung, bronch...

Porcine reproductive and respiratory syndrome virus (PRRSv) causes substantial economic impact due to significant losses in productivity. Thus, measuring changes in farm productivity before and after PRRS infection enables quantifying the production and economic impact of outbreaks. This study assessed the application of exponentially weighted moving average (EWMA), a statistical process contro...

Host pattern-recognition receptors (PRRs) recognize pathogen-associated molecular patterns generated by invading viruses and initiate a series of signaling cascades that lead to the activation of interferon-regulatory factor 3 (IRF3) and nuclear factor-κB (NF-κB) and subsequent induction of type I interferons (IFNs). Posttranslational modification of proteins by ubiquitin plays an essential rol...

Bacteraemia and viraemia are characterised by pathogens entering the bloodstream. Endothelial cells are among the first cells coming into contact with the microbes and also some endogenous molecules which are released by tissue damage. As part of the innate immune system, endothelial cells respond to these contacts by producing inflammatory mediators and expressing surface molecules. The initia...

Porcine reproductive and respiratory syndrome (PRRS) is considered to be one of the most costly diseases affecting intensive pig production worldwide. Control of PRRS is a complex issue and involves a combination of measures including monitoring, diagnosis, biosecurity, herd management, and immunization. In spite of the numerous studies dealing with PRRS virus epidemiology, transmission of the ...

SAS: Iowa Select Farms, Iowa Falls, Iowa 50126, e-mail: [email protected]; JJZ: Iowa State University; MBR: NOBL Laboratories orcine reproductive and respiratory syndrome (PRRS) was first reported in the United States in 19871,2 and has since become widespread throughout the swine-producing areas of the country.3 The two main strategies used to limit losses to PRRS virus (PRRSV) infectio...

El Síndrome Respiratorio y Reproductivo del Cerdo (PRRS) es una enfermedad endémica en porcinos que tiende a la cronicidad. Los esfuerzos se centran prevención control para minimizar el daño, pues no existe tratamiento. Se evaluó efecto de adición ácido docosahexaenoico (DHA) oleorresina cúrcuma capsicum (EP, extractos plantas) alimentación cerdas reproductoras afectadas con PRRS sobre su desem...

Pattern recognition receptors (PRRs) evolved to protect organisms against pathogens, but excessive signaling can induce immune responses that are harmful to the host. Putative PRR dysfunction is associated with numerous immune disorders that affect the skin, such as systemic lupus erythematosus, cryopyrin-associated periodic syndrome, and primary inflammatory skin diseases including psoriasis a...