Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT), through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve th...

Proton therapy represents a technologically advanced method for delivery of radiation treatments to tumors. The determination the biological effectiveness is one objectives MoVe IT (Modeling and Verification Ion Beam Treatment Planning) project National Institute Nuclear Physics (INFN) CSN5. aim present work, which part project, was evaluate performance thermoluminescent dosimeters (TLDs-100) d...

PURPOSE To characterize and quantify the distal edge activity fall off, created in a phantom by a proton therapy beam METHOD AND MATERIALS: A 30×30×10cm polymethylmethacrylate phantom was irradiated with a proton therapy beam using different ranges and beams. The irradiation volume is approximated by a right circular cylinder of diameter 7.6cm and varying lengths. After irradiation, the phantom...

background: recent studies in eye plaque brachytherapy have shown a considerable difference between the dosimetric results using water phantom and a model of human eye containing realistic materials. in spite of this fact, there is a lack of simulation studies based on such a model in proton therapy literatures. in the presented work, the effect of utilizing an eye model with ocular media on pr...

The microdosimetric kinetic model (MKM) is widely used for estimating relative biological effectiveness (RBE)-weighted doses for various radiotherapies because it can determine the surviving fraction of irradiated cells based on only the lineal energy distribution, and it is independent of the radiation type and ion species. However, the applicability of the method to proton therapy has not yet...

Introduction: Nowadays, cancer is one of the most important concerns in human being's societies, more than one-third of people in around the world will get cancer during their lives. Physical dose depth distribution characteristic of protons in a tissue is determined with a low dose in the entrance region, maximum dose in the Bragg region, and rapid decline takes place near the...

Proton therapy is a rapidly progressing field for cancer treatment. Globally, many proton therapy facilities are being commissioned or under construction. Secondary neutrons are an important issue during the commissioning process of a proton therapy facility. The purpose of this study is to model and validate scanning nozzles of proton therapy at Samsung Medical Center (SMC) by Monte Carlo simu...

To account for particle interactions in the extracellular (physical) environment, information from the cell-level Monte Carlo damage simulation (MCDS) for DNA double strand break (DSB) induction has been integrated into the general purpose Monte Carlo N-particle (MCNP) radiation transport code system. The effort to integrate these models is motivated by the need for a computationally efficient ...