Computational identification of special protein molecules is a key issue in understanding protein function. It can guide molecular experiments and help to save costs. I assessed 18 papers published in the special issue of Int. J. Mol. Sci., and also discussed the related works. The computational methods employed in this special issue focused on machine learning, network analysis, and molecular ...

Introduction Proteins are one of the major biological macromolecules performing a variety functions such as enzymatic catalysis, transport, regulation of metabolism, nerve conduction, immune response etc. The three-dimensional structure of a protein is responsible for its function. In this paper I wish to give an overview of the need for protein structure prediction, the different approaches av...

Microtubule Affinity-Regulating Kinase 2 (MARK2) protein has a substantial role in regulation of vital cellular processes like induction of polarity, regulation of cell junctions, cytoskeleton structure and cell differentiation. The abnormal function of this protein has been associated with a number of pathological conditions like Alzheimer disease, autism, several carcinomas and development of...

background : the aim of this study was to generate in silico 3d-structure of the envelope protein of ahfv using homology modeling method to further predict its conformational epitopes and help other studies to investigate its structural features using the model. methods : a 3d-structure prediction was developed for the envelope protein of alkhumra haemorrhagic fever virus (ahfv), an emerging ti...

Non-specific electrostatics is crucial for structure and stability; recently, it has been argued that psychrophilic proteins may also utilize specific electrostatic interactions. Do increase the number of salt bridges cold adaptation? Are there any changes occur in their sequence, which helps them to adapt an extreme environment? intra-protein interactions affect stability? Is special type inte...