Elucidating kinetic processes of protein-protein interactions (PPI) helps to understand how basic building blocks affect overall behavior of living systems. In this study, we used structure-based properties to build predictive models for kinetic constants of PPI. A highly diverse PPI dataset, protein-protein kinetic interaction data and structures (PPKIDS), was built. PPKIDS contains 62 PPI wit...

Proteins interact in complex protein-protein interaction (PPI) networks whose topological properties-such as scale-free topology, hierarchical modularity, and dissortativity-have suggested models of network evolution. Currently preferred models invoke preferential attachment or gene duplication and divergence to produce networks whose topology matches that observed for real PPIs, thus supportin...

Abstract Background The skin is the largest organ of body and has multiple functions. Wounds remain a significant healthcare problem due to large number traumatic pathophysiological conditions patients suffer. Methods Gene expression profiles 37 biopsies collected from undergoing split-thickness grafts at five different time points were downloaded two datasets (GSE28914 GSE50425) in Expression ...

Abstract In the last months, many studies have clearly described several mechanisms of SARS-CoV-2 infection at cell and tissue level, but interaction between host SARS-CoV-2, determining grade COVID-19 severity, are still unknown. We provide a network analysis on protein–protein interactions (PPI) viral proteins to better identify biological responses, induced by both whole proteome specific pr...

Introduction Industrial applications of lentil (LP) and quinoa (QP) proteins are limited due to their relatively poor water solubility. In this study, a combination protein-protein interaction (PPI) fermentation was used improve the functionality nutritional value LP by conjugating them with QP. The reaction conditions between QP for producing these conjugates were established. Methods ratio eq...

Protein-protein interaction (PPI) networks available in public repositories usually represent relationships between proteins within the cell. They ignore the specific set of tissues or tumors where the interactions take place. Indeed, proteins can form tissue-selective complexes, while they remain inactive in other tissues. For these reasons, a great attention has been recently paid to tissue-s...

Almost every cellular process requires the interactions of pairs or larger complexes of proteins. High throughput protein-protein interaction (PPI) data have been generated using techniques such as the yeast two-hybrid systems, mass spectrometry method, and many more. Such data provide us with a new perspective to predict protein functions and to generate protein-protein interaction networks, a...

MOTIVATION Protein-protein interaction (PPI) extraction from published biological articles has attracted much attention because of the importance of protein interactions in biological processes. Despite significant progress, mining PPIs from literatures still rely heavily on time- and resource-consuming manual annotations. RESULTS In this study, we developed a novel methodology based on Bayes...

Background: The radiation resistance process is a major problem in radiotherapy. Proteomics useful method to determine the molecular mechanism of biological and medical events. Protein-protein interaction (PPI) network suitable for proteomics data interpretation. Objectives: Assessment about human cell lines via PPI analysis aim this study. Methods: Proteomic were extracted from literature diff...