Background. Prostate-specific antigen (PSA) is a glycoprotein produced by the prostate gland and its production can be enhanced in benign and malignant diseases. The introduction of PSA testing has greatly increased the detection of prostate cancer. However there is continuing controversy and confusion over the most appropriate application of the PSA test. Methods. PubMed and Web of Science dat...

Background. Prostate-specific antigen (PSA) is a glycoprotein produced by the prostate gland and its production can be enhanced in benign and malignant diseases. The introduction of PSA testing has greatly increased the detection of prostate cancer. However there is continuing controversy and confusion over the most appropriate application of the PSA test. Methods. PubMed and Web of Science dat...

In recent years, there has been considerable controversy concerning the discovery and translation into clinical practice of the prostate-specific antigen (PSA) [1e4]. In this brief review, I offer the relevant historical facts as I believe them to be true. Before the development of the PSA blood test, prostatic acid phosphatase was the most important blood test for prostate cancer, but it was o...

BACKGROUND The serum prostate specific antigen for the early detection and screening for prostate cancer are very common used among physicians as the best screening tool for prostate cancer. The result of prostate specific antigen levels discriminates whether or not a prostate biopsy should be performed. The lack of specificity is a limitation of PSA as tumor marker, increased PSA concentration...

Received 6/20/2005; revised 10/1/2005; accepted 10/5/2005. For correspondence or reprints contact: Daw-Guey Tsay, M.D., Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung 813, Taiwan, ROC. Tel: (886)7-3468206 Fax: (886)7-5544762 E-mail: [email protected] In our radioimmunoassay laboratory, we handled around 110,000 blood samples for pros...

Indications of prostate biopsy are high serum prostate specific antigen (PSA) value and or abnormal digital rectal examination (DRE) findings. Although serum PSA value of 4 ng/ml is the most commonly used threshold for recommending prostate biopsy, significant proportion of men harbor prostate cancer even when their serum PSA values are less than 4.0 ng/ml. Therefore present study was designed ...

Serum prostate-specific antigen (PSA) is an effective diagnostic tool for detection of prostate cancer (CaP) at an early and potentially curable stage, but specificity is low. Studies have shown that the proportion of serum PSA complexed with alpha-1-antichymotrypsin (ACT) is higher in men with CaP than in men with benign prostate disease. We developed a novel immunoassay for complexed PSA base...

INTRODUCTION The objective of this study was to evaluate the value of serum prostate-specific antigen (PSA) and prostate-specific antigen density (PSAD) in the diagnosis of prostate cancer. MATERIALS AND METHODS A total of 330 consecutive patients suspected of having prostate cancer due to either abnormal digital rectal examination or elevated serum PSA levels underwent transrectal ultrasonog...

Many candidate biomarkers for diagnosis of prostate cancer have been investigated, but prostate-specific antigen (PSA) testing remains the frontline test for both mass screening and individual clinical testing. Although the PSA test is cost-effective, analytically reliable, and flexibly high throughput, it has a very weak correlation with prostate malignancy. This has resulted in over-diagnosis...

The study was conducted on 90 serum samples of people with prostate diseases (G1-include 24 for patients cancer-PC , G2- include benign prostatic hyperplasia-BPH and 22 prostatitis G3), compared 20 healthy individuals as control group. Prostate-specific antigen-PSA, human kallikrein-2-hK2, fibrinogen gamma-FGG, total anti-oxidant capacity-TAC, Vitamin D3-VD3. results showed that the activity PS...