background: beta-adrenergic blocking agents have been broadly used for treatment of many cardiovascular diseases such as arterial hypertension and ischemic heart failure. anti-tumoral, anti-inflammatory and anti-angiogenesis effects of propranolol (a non-selective beta-adrenergic blocker) have been shown. angiogenesis (replenish of the pre-existing vascular networks) plays a critical role in so...

abstract background: prolonged labor can lead to maternal and neonatal complications. the purpose of this study was to investigate the effect of oral propranolol plus oxytocin versus oxytocin only on the process and outcome of labor. materials and methods: in a randomized, double-blind, controlled trial performed in ilam mustafa hospital, a total of 146 nulliparous pregnant women at gestational...

BACKGROUND Hemangiomas are the most common benign tumors of infancy. This study evaluated the efficacy of oral propranolol comparing to oral steroids in management of pediatric hemangiomas. METHODS In North India from January 2012 to January 2015, sixty children <6 years old with superficial hemangiomas were divided into 2 groups; oral propranolol vs. oral prednisolone. All participants we...

This paper gives a new integrable hierarchy of nonlinear evolution equations. In this hierarchy there are the following representative equations: ut = ∂ 5 xu − 2 3 , ut = ∂ 5 x (u 1 3 )xx − 2(u 1 6 )x u ; uxxt + 3uxxux + uxxxu = 0. The first two are in the positive order hierarchy while the 3rd one is in the negative order hierarchy. The whole hierarchy is shown integrable through solving a key...

Propranolol, a nonselective β-adrenergic receptor blocker, is the first-line medical treatment for severe infantile hemangiomas (IH). We have shown in mice that propranolol-induced tumor growth inhibition was correlated with altered expression of Aquaporin-1 (AQP1), an aqueous channel modulated angiogenesis and cell migration. In IH, AQP1 made it possible to identify interstitial named telocyte...

The technique of non-invasive blood pressure monitoring was used to compare the 24-hr control of blood pressure in 10 patients with essential hypertension taking either twice daily propranolol or a once daily long-acting formulation of propranolol (propranolol LA). Both drug regimes produced smooth control of blood pressure and heart rate through the 24 hours and significantly reduced blood pre...

Introduction: Previous studies have demonstrated that the &beta-adrenergic receptor antagonist propranolol impairs fear memory reconsolidation in experimental animals. There are experimental parameters such as the age and the strength of memory that can interact with pharmacological manipulations of memory reconsolidation. In this study, we investigated the ability of the age and the strength o...

1 Cetamolol is a new 3-adrenoceptor blocking agent shown in animals to have moderate PI -adrenoceptor selectivity and partial agonist activity. 2 In healthy normal volunteers, PI -adrenoceptor blockade was measured as the reduction of exercise-induced tachycardia, systolic blood pressure, and double product at 2, 8, and 24 h after a single oral dose of 10, 25, and 50 mg cetamolol. 3 P1-adrenoce...

the effect of different kinds of surfactants in various concentrations incorporated in an inert matrix, on the release of procainamide hydrochloride, as a cationic model compound, was investigated in this study. sodium lauryl sulfate and sodium stearate as anionic surfactants, cetyl pyridinium chloride and cetyltrimethyl ammonium bromide as cationic and span 60 and tween 80 as non-ionic surfact...