BACKGROUND During long-term intravenous infusions, sulfite in sulfite-containing propofol emulsions can cause the peroxidation of lipid and dimerization of propofol. This study evaluated the role of lipid in sulfite-dependent propofol dimerization by determining the effects of individual fatty acids in soybean oil emulsion and peroxidized lipids in a model system. METHODS Individual fatty aci...

BACKGROUND the present study was designed to compare the efficacy, tolerability and safety of dexmedetomidine and fentanyl when combined with propofol during extracorporeal shock wave lithotripsy in children. METHODS fifty children aged 3-8 years, the American Society of Anesthesiologists status I and II, scheduled for elective extracorporeal shock wave lithotripsy were randomly allocated to ...

Objective: The key objective of the study is to compare Propofol-based total intravenous anaesthesia (TIVA) with Isoflurane-based inhalational for controlled hypotension during functional endoscopic sinus surgery (FESS). Materials and Methods: This a prospective randomized, single-blinded clinical study. involved 40 patients posted elective FESS surgery, selected randomly from ENT department. A...

BACKGROUND Propofol is increasingly used in paediatric anaesthesia, but can be challenging to titrate accurately in this group. Mid-latency auditory-evoked potentials (MLAEPs) can be used to help titrate propofol. However, the effects of propofol on MLAEP in children are unclear. Therefore, we investigated the relationship between propofol and MLAEP in children undergoing anaesthesia. METHODS...

OBJECTIVES Propofol (2, 6-diisopropylphenol) is an intravenous anesthetic that is commonly used for the general anesthesia. It is well known that the spinal cord is one of the working targets of general anesthesia including propofol. However, there is a lack of investigation of the effects of propofol on spinal dorsal horn which is important for the sensory transmission of nociceptive signals. ...

Background A wide range of drugs are used for sedation in gastrointestinal (GI) endoscopy procedures, including midazolam, dexmedetomidine, and ketamine. Therefore, this study aimed to compare the effects these combination with propofol among cancer patients undergoing GI endoscopy.Methods This randomized, double-blinded was carried out on 75 who underwent endoscopy. Patients were categorized i...

background antioxidant effects of propofol (2, 6-diisopropylphenol) were evaluated against cisplatin-i‎nduced oxidative stress in rat. objectives in this experimental study, 20 male rats were equally divided into 4 groups (5 rats each), and were treated by propofol (10 mg/kg/day, ip), or cisplatin (7 mg /kg/day, ip), or both. conclusions it is concluded that oxidative ‎damage is the mechanism o...

background the anesthesia planning is an important and determining factor in the amount of intraoperative hemorrhage, which can affect the rate of intraoperative and postoperative complications. objectives in this study we used two different anesthesia techniques in functional endoscopic sinus surgery (fess) and compared the amount of hemorrhage in the two groups. patients and methods in a sing...

BACKGROUND It is increasingly believed that acute microvascular alterations may be involved in the development of organ dysfunction in critically ill patients. Propofol significantly decreases vascular tone and venous return, which can induce arterial hypotension. However, little is known about the microcirculatory effects of propofol in healthy humans. METHODS We conducted a prospective, ope...