Acne vulgaris is the most common disorder seen in ambulatory dermatology practice. Acne causes significant morbidity and the direct costs associated with it exceed $2.2 billion per year in the United States (U.S.). The pathogenesis is multifactorial, and our understanding of the mechanisms involved in the development of acne lesions has improved with time. Follicular hyperkeratinization, sebum ...

BACKGROUND To test the hypothesis that the oral cavity is a potential source for implantable pacemaker and cardioverter defibrillators infections, the bacterial diversity on explanted rhythm heart management devices was investigated and compared to the oral microbiome. METHODS A metagenomic approach was used to analyze the bacterial diversity on the surfaces of non-infected and infected pacem...

Felty's syndrome, first reported by Felty in 1924 [1], is well known as a trio of rheumatoid arthritis, splenomegaly, and neutropenia, which occurs in 1-5% of patients with rheumatoid arthritis. The nephropathy associated with Felty's syndrome is very rare; we found only one previous case in the literature [2]. Although the pathogenesis of Felty's syndrome is still unclear, the glomerular lesio...

We investigated the in vitro susceptibilities of 23 Propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime by utilizing the Etest. The MICs ranged from 0.094 microg/ml to 0.75 microg/ml, 0.094 microg/ml to 1.5 microg/ml, and 1 microg/ml to 12 microg/ml for ertapenem, meropenem, and cefepime, respectively. Based on our excellent in vitro carbapenem susceptibility resul...

A 49-year-old man with pulmonary sarcoidosis was admitted to our hospital because of nephrotic syndrome. Renal biopsy revealed membranous nephropathy and granulomatous interstitial nephritis. DNA and cell membrane constituents of Propionibacterium acnes were detected in the patient’s glomeruli and tubular epithelial cells. Treatment with corticosteroids and an antimicrobial agent resulted in re...

Propionibacterium acnes is a gram-positive anaerobic microorganism recognized as the major skin bacterium causing acne. Clove essential oil is the extract of Syzygium aromaticum (L) Merr et Perry. Its antimicrobial property has been reported, but to our knowledge its antibacterial activity toward P acnes and the mechanism of action have not been reported. Methods. Agar diffusion and broth micro...

Propionibacterium acnes, P. avidum, and P. granulosum were quantitatively measured in 50 young adults. The scalp, forehead, external auditory canal, alae nasi, anterior nares, groin, rectum, and antecubital and popliteal fossa were sampled. These represent various cutaneous microenvironments, differing in moisture, density of sweat, sebaceous glands, and extent of anaerobiosis. These studies sh...

Felty's syndrome, first reported by Felty in 1924 [1], is well known as a trio of rheumatoid arthritis, splenomegaly, and neutropenia, which occurs in 1-5% of patients with rheumatoid arthritis. The nephropathy associated with Felty's syndrome is very rare; we found only one previous case in the literature [2]. Although the pathogenesis of Felty's syndrome is still unclear, the glomerular lesio...