Purpose: The aim of the present study was to enhance oral bioavailability curcumin using different surfactant and vehicle for preparing proniosomal gel. Methods: Curcumin comes under BCS Class IV which is having low solubility permeability poor bioavailability. Buccal drug delivery can bypass such problems leads increase in Proniosomes offer excellent potential improved through versatile routes...

Skin has become an impressive and idealistic platform for the delivery of drugs compared to other routes. However, the stratum corneum “dead, impermeable barrier devoid of biological activity” to skin had challenged the development of transdermal product, which delivers the drugs directly to the systemic circulation at a controlled rate. Recent literature suggests the old doctrine, which states...

PURPOSE Lipid suspensions as drug carriers, including conventional liposomes, ethosomes, transferosomes, proniosomes, niosomes, PEG-PPG-PEG niosomes and stratum corneum liposomes (cerosomes), were formulated and compared. METHODS Lipid vesicles were formulated and assessed with regards to enhancement of skin permeation of diclofenac and stability profiles of the formulations. Formulation-indu...