BACKGROUND Prolactin performs as a neuroendocrine modulator of skin epithelial cell proliferation and the skin immune system. OBJETIVE The aim was to assess the serum prolactin levels in patients with atopic dermatitis and the relationship with disease severity. METHODS The study was performed on 46 patients with atopic dermatitis and 100 healthy controls aged between 0.5 years and 19.5 yea...

The authors explored whether prolactin is associated with paternal care in 3 monkey species: titi monkey (Callicebus cupreus), common marmoset (Callithrix jacchus), and Goeldi's monkey (Callimico goeldii). They compared prolactin levels in fathers before and after infant birth as well as between fathers and nonfathers. C. cupreus fathers carry infants almost exclusively, have higher prolactin l...

1. Central dopaminergic pathways are possibly related to noradrenergic tone and may be important in the pathogenesis of essential hypertension. Basal plasma prolactin levels have been used as a marker of dopaminergic activity in the hypothalamus. The prolactin response to thyrotropin-releasing hormone (TRH) gives evidence of the dynamics of prolactin secretion. 2. To evaluate further the role o...

............................................................................................................................. 3 TABLE OF CONTENTS......................................................................................................... 4 LIST OF PUBLICATIONS..................................................................................................... 6 LIST OF ABBREVIATION...

Hypersecretion of prolactin by lactotroph cells of the anterior pituitary may lead to hyperprolactinemia in physiological, pathological and idiopathic conditions. Most patients with idiopathic hyperprolactinemia may have radiologically undetected microprolactinomas, but some may present other causes of hyperprolactinemia described as macroprolactinemia. This condition corresponds to the predomi...

A radioimmunoassay for primate prolactin has been developed, with [(131)I] monkey prolactin, and antibodies to monkey or human prolactin. The assay is specific for prolactin; human growth hormone, and human and monkey placental lactogen show no significant crossreaction. The assay is sensitive enough to measure prolactin concentrations in the sera of most humans studied. The concentration of pr...

Described is a two-chromatographic-step preparative-scale technique for the purification of human prolactin from a frozen pituitary homogenate. The method utilizes hydrophobic interaction chromatography on the mildly hydrophobic adsorbent phenyl-Sepharose CL-4B and anion-exchange chromatography on DEAE-cellulose in the presence of acetonitrile. Human prolactin was solubilized at pH10.0 after a ...

There is an inverse relation between zinc (Zn) intake and plasma prolactin in men and nonpregnant women. Whether a relation exists in lactating women is unknown, despite the potential consequences of perturbations in prolactin regulation on lactation performance. We examined the effects of low Zn intake on prolactin concentration, the prolactin regulatory pathway in the pituitary gland, and lac...

Prolactin is a dual function protein that functions both as a hormone as well as a cytokine (Ben-Jonathan et al., 1996). Prolactin is synthesized and secreted from pituitary gland and its primary role is to help initiate and maintain breast milk production in pregnant and nursing women (PRL prolactin). Prolactin is also synthesized and secreted from the cells of the immune system such as macrop...

The changes in the serum prolactin levels during 8 ovulatory cycles, 3 anovulatory cycles, 3 clomiphene treated cycles, 4 premarin treated cycles and 2 cycles which had just become pregnant were measured by our heterologous radioimmunoassay. Serum prolactin levels showed an increase in the ovulatory phase in 6 out of 8 ovulatory women and in the luteal phase in 5 out of 8 ovulatory women respec...