Oncolytic viruses (OVs) remodel the tumor microenvironment by switching a “cold” into “hot” with high CD8+ T-cell infiltration. activity plays an essential role in antitumor efficacy of OVs. However, T cells is impaired programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) interaction. To date, it remains unclear why OVs alone have significant even when PD-L1 expression persist...

Background: This study aimed to estimate peripheral blood lymphocyte subsets and programmed death receptor-1 positive (PD-1+) proportions of T cells, their impact on progression free survival (PFS) radiological response in lung cancer.

the objective of this study was to observe the apoptosis-inducing effect and mechanism of baicalin on human cervical cancer hela cells. the inhibitory effect of baicalin on the growth of hela cells was measured by mtt assay, and cell proliferation and migration was analyzed by cell scratch assay. morphological changes of apoptotic cells were viewed by the light microscope and electron microscop...

Aims: Programmed cell death ligand 1 (PD-L1) is the of programmed (PD-1), which a host immunity inhibitory receptor. Expression PD-L1 in diverse tumor types has been widely discussed, while there little research about intrinsic-PD-1. Phospho-S6 (p-S6) an important downstream effector PI3K/AKT/mTOR pathway. Our study was focused on investigating expression cancer cell-intrinsic PD-1, and p-S6 pr...