نتایج جستجو برای: programmed cell death 1 ligand 2 protein
تعداد نتایج: 5723882 فیلتر نتایج به سال:
Purpose The purpose of this study was to optimize a peptide (nABP284) that binds programmed cell death protein 1 (PD-1) by computer-based protocol in order increase its affinity. Then, aimed determine the inhibitory effects on cancer immune escape coculturing improving cytokine-induced killer (ICIK) cells with cells. Materials and Methods nABP284 PD-1 identified phage display technology our pre...
PURPOSE The negative regulatory programmed death-1/programmed death-1 ligand (PD-1/PD-L) pathway in T-cell activation has been suggested to play an important role in tumor evasion from host immunity. In this study, we investigated the expression of PD-L1 and PD-L2 in human esophageal cancer to define their clinical significance in patients' prognosis after surgery. EXPERIMENTAL DESIGN PD-L1 a...
Expression of the PD-1 receptor on T cells has been shown to provide an important inhibitory signal that down-modulates peripheral effector responses in normal tissues and tumors. Furthermore, PD-1 up-regulation on chronically activated T cells can maintain them in a partially reversible inactive state. The function of PD-1 in the very early stages of T-cell response to antigen in vivo has not ...
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