The myriad genetic associations with idiopathic (primary) generalized epilepsies (IGE) are challenging to both researchers and caregivers. There are numerous mutations, among them voltagegated sodium, potassium, and calcium channels and ligand-gated GABA receptors. A variety of mutations may produce similar phenotypes, while, equally troublesome, single mutations may produce a range of phenotyp...

PROBLEM Puzzling, progressive profusion of alliterative "p's" in published papers. PURPOSE To depict this particular "p" predominance with pinpoint precision. PLAN: Periodic, painstaking perusal of periodicals by a professor of paediatrics. PROPOSAL The "p" plethora is positively perplexing and potentially perturbing.

STUDY OBJECTIVE To reexamine the symptoms, lung function, and chest radiographs of older gold miners who continued to work in or around gold mines 5 years after their enrollment in the cohort. DESIGN A follow-up study of a stratified sample of a cohort of gold miners. SETTING A health-care center for 24 gold mines in Welkom, South Africa. POPULATION A stratified, random sample of 242 mine...

OBJECTIVES To investigate the risk factors predicting radiological progression in silicosis in a prospective cohort study of patients with silicosis who were previously exposed to silica from granite dust. METHODS From among a total of 260 patients with silicosis contracted from granite work, 141 with available serial chest x ray films of acceptable quality taken over a period of 2 to 17 (mea...

Plain chest radiographs from a one in six random sample of the workforce of the asbestos industry at Wittenoom, Western Australia between 1943 and 1966 have been classified for degree of profusion and pleural thickening by two independent observers according to the 1980 UICC-ILO Classification of Radiographs for the pneumoconioses to clarify the effect of degree of radiological abnormality on s...

Imaging is essential for evaluating patients with glioblastoma. Traditionally a multimodality undertaking, CT, including CT cerebral blood profusion, PET/CT traditional fluorine-18 fluorodeoxyglucose (18F-FDG), and MRI have been the mainstays diagnosis post-therapeutic assessment. However, recent advances in these modalities, league emerging fields of radiomics theranostics, may prove helpful i...

Open Source software licenses permit the free sharing and improvement of Open Source software source code for which the community of Open Source software has flourished. However, these communities suffer from a lack of contribution and a profusion of “Free-Riding”. Different innovation models and game theoretic principles can thus, be applied to view this phenomenon more logically and even be s...

Thirty three consecutive untreated patients with pulmonary sarcoidosis, confirmed histologically or by Kveim test, were investigated to correlate cell counts in bronchoalveolar lavage fluid with clinical features, the chest radiograph, and results of lung function tests. A persistently abnormal radiograph had been observed for one year or more in 26 (79%) and for two years or more in 20 (61%), ...