نتایج جستجو برای: prodh
تعداد نتایج: 467 فیلتر نتایج به سال:
The bifunctional flavoenzyme proline utilization A (PutA) catalyzes the two-step oxidation of proline to glutamate using separate proline dehydrogenase (PRODH) and l-glutamate-γ-semialdehyde dehydrogenase active sites. Because PutAs catalyze sequential reactions, they are good systems for studying how metabolic enzymes communicate via substrate channeling. Although mechanistically similar, PutA...
Proline utilization A from Escherichia coli (EcPutA) is a multifunctional flavoenzyme that oxidizes proline to glutamate through proline dehydrogenase (PRODH) and Δ1-pyrroline-5-carboxylate dehydrogenase (P5CDH) activities, while also switching roles as a DNA-bound transcriptional repressor and a membrane-bound catabolic enzyme. This phenomenon, termed functional switching, occurs through a red...
evidence is emerging for the association of polymorphisms in prodh gene and increased risk of schizophrenia. in this project, peripheral blood sampling was obtained from 175 schizophrenia patients that their diseases were confirmed by psychiatrists. 185 healthy individuals were considered as control group. the related tests were administered on the basis of pcr-rflp. in the continuation, statis...
Vaccination started on the East Indian Kailway in 1884 as a systematic work the records of which are not available before 1893, the 19 years recorded here show a progressive protection of the railway staff with a very small incidence of small-pox cases. Those numbers would hardly appeal to an English audience, where universal vaccination, until the conscientious objector stepped in, had made sm...
Proline utilization A (PutA) from Bradyrhizobium japonicum (BjPutA) is a bifunctional flavoenzyme that catalyzes the oxidation of proline to glutamate using fused proline dehydrogenase (PRODH) and ∆-pyrroline-5-carboxylate dehydrogenase (P5CDH) domains. Recent crystal structures and kinetic data suggest an intramolecular channel connects the two active sites, promoting substrate channeling of t...
Metabolite quantitative traits carry great promise for epidemiological studies, and their genetic background has been addressed using Genome-Wide Association Studies (GWAS). Thus far, the role of less common variants has not been exhaustively studied. Here, we set out a GWAS for metabolite quantitative traits in serum, followed by exome sequence analysis to zoom in on putative causal variants i...
Aromatic rice is highly prized by consumers worldwide due to its special aromatic character. 2-acetyl-1-pyrroline (2-AP) is considered to be the single most important volatile compound responsible for aroma in aromatic rice. The present study demonstrated the effects of 2-AP, zinc (Zn) and lanthanum (La) on the 2-AP concentration of detached aromatic rice panicles in vitro. Detached panicles fr...
Despite decades of research being conducted to understand what physiological deficits in the brain are an underlying basis psychiatric diseases like schizophrenia, it has remained difficult establish a direct causal relationship between neuronal dysfunction and specific behavioral phenotypes. Moreover, remains unclear how metabolic processes, including amino acid metabolism, affect function con...
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