DISEASE OVERVIEW Approximately one-fourth of cutaneous lymphomas are B-cell derived and are generally classified into three distinct subgroups: primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma (PCMZL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT). DIAGNOSIS DIAGNOSIS and disease classification is based on histologic re...

BACKGROUND Primary cutaneous B-cell lymphoma (PCBCL) is a heterogeneous group of rare clonal B-cell lymphoproliferative disorders with distinct clinicopathologic features from more common nodal B-cell lymphomas. METHODS We performed a systematic review of the relevant literature in the MEDLINE database and analyzed laboratory and clinical data. This review discusses the three most common type...

BACKGROUND Anaplastic large cell lymphoma (ALCL) is one type of lymphoma, which is characterized by the proliferation of pleomorphic large atypical lymphoid cells expressing CD30 antigen. ALCL involving skin can be either primary cutaneous disease or cutaneous involvement secondary from systemic disease. Data of clinical manifestation of cutaneous ALCL in Thai patients is limited. ALCL in Thai ...

Background: Primary cutaneous T cell lymphoma is a diverse and rare group of diseases with clinical manifestations that, if not biopsied, are easily confused benign skin diseases. Objective: To determine some features primary lymphomas classify them according to the 2018 update World Health Organization European Organisation for Research Treatment Cancer classification. Methods: case series stu...

BACKGROUND Primary cutaneous T-cell lymphomas constitute a heterogeneous and rare group of diseases with regional particularities in Latin America. OBJECTIVE To determine the clinicopathological features, relative frequency and survival among patients from a Peruvian institution. METHODS Primary cutaneous T-cell lymphomas were defined based on the absence of extracutaneous disease at diagno...

Cutaneous T cell lymphoma (CTCL) is a broad diagnostic group encompassing a spectrum of diseases with variable clinical presentations. Histologic and immunohistochemical confirmation is needed to establish a precise diagnosis. Primary cutaneous CD 30+ anaplastic large cell lymphoma, a definite variety of CTCL, presenting as a non-healing ulcer is presented here which, needed multimodality appro...

Primary cutaneous B-cell lymphoma, leg type, is an uncommon and aggressive subtype of Primary cutaneous B cell lymphoma that is recently updated by the World Health Organization–European Organization for Research and Treatment of Cancer classification of cutaneous lymphomas. We present a case of an 80-year-old woman who presented with redness and swelling mimicking cellulitis of her right leg, ...

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and primary cutaneous gamma delta T-cell lymphoma (PCGD-TCL) were initially both classified as subcutaneous panniculitis-like T-cell lymphoma. In 2008, SPTCL with alpha-beta T-cell receptor subtype was separated from primary cutaneous gamma delta T-cell lymphomas (PCGD-TCL). We report four pediatric cases that demonstrate the heterogeneity ...

old world cutaneous leishmaniasis (owcl) usually causes a single, self-healing and uncomplicated lesion mainly on the exposed area of body. this report presents four cases of owcl from iran that misdiagnosed with sarcoidosis, lymphoma, and acne agminata. two out of four patients showed a history of purplish red plaques for at least 5 years who misdiagnosed as sarcoidosis because of histological...

The primary cutaneous marginal zone B cell lymphoma is a small B cell lymphoma, including cells of the marginal zone, lymphoplasmacytic cells, and plasma cells. Clinically it manifests as erythematous or erythematous-violaceous papules, plaques, or nodules, single or multiple, most often located to the extremities. Its course is usually indolent, with a survival at 5 years of approximately 97 p...