Osteosarcoma is the most common primary bone malignancy in children and adolescents. Herein, we investigated the role of cluster of differentiation 44 (CD44), a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion, and migration in osteosarcoma. We constructed a human osteosarcoma tissue microarray with 114 patient tumor specimens, including tumor tissues from primary, me...

Background: The present study was aimed to study the CT and MRI features of primary osteosarcoma in children and their diagnostic values. Methods: 56 patients with primary osteosarcoma diagnosed by pathology were examined using both CT

Osteosarcoma is a malignant intra-osseous neoplasm producing osteoid. of the skull very rare and it usually involves cranial vault. The occurrence in base extremely rare. We report case primary osteosarcoma 59-year-old lady, occur left sphenoid wing with intracranial intranasal extension manifesting as facial pain, headache epistaxis. She underwent radiotherapy surgical resection tumour not fea...

Dear Editor, Primary pure osteosarcoma of the breast is a rare malignant tumour and is histologically indistinguishable from conventional osteosarcoma of the bone and other extraskeletal sites. Being a rare entity that is briefl y reported in the radiology literature, it has some interesting imaging features worthy of discussion. Here we report the novel fi ndings of dynamic contrast-enhanced M...

To the Editor: We have read with great interest the article by Gu and coworkers reporting the coxsackievirus and adenovirus receptor (CAR) status on primary musculoskeletal tumors (1). We are particularly interested in their findings on osteosarcomas because we are developing gene therapy strategies for this cancer. CAR is the high-affinity viral receptor for most human adenovirus serotypes inc...

BACKGROUND Primary intracranial osteosarcoma is a extremely rare disease entity. We describe a case of primary intracerebral osteosarcoma in an adult brain. CASE DESCRIPTION A patient who presented with a 1-week history of headaches, and MRI examination was performed. The immunohistochemical diagnosis confirmed primary intracerebral osteosarcoma. The patient was treated with a surgical resect...

The aim of this study was to evaluate the status and explore the impact of DNA methylation of WNT6 gene with osteosarcoma in children. A total of 50 patients with primary osteosarcoma in children were enrolled. The expression of WNT6 protein was determined by immunohistochemical staining. The DNA methylation level of WNT6 gene was evaluated by methylation-specific PCR (MSP). Human MG63 osteosar...

Osteosarcoma is the most frequent malignant primary bone tumor and a main cause of cancer-related death in children and adolescents. Although long-term survival in localized osteosarcoma has improved to about 60% during the 1960s and 1970s, long-term survival in both localized and metastatic osteosarcoma has stagnated in the past several decades. Thus, current conventional therapy consists of m...

INTRODUCTION Primary osteosarcoma is one of the rare tumors affecting the urinary bladder. The occurrence of osteosarcoma in a patient with a long history of transitional cell carcinoma of the bladder is even more uncommon. CASE PRESENTATION We present the case of a 74-year-old Greek man who was diagnosed with osteosarcoma 10 years after he had been diagnosed with transitional cell carcinoma ...