An efficient sequential four-component reaction of chromone carbaldehydes, Meldrum's acid, 4-hydroxyl coumarin or 6-methyl-4-hydroxyl-pyrone and primary alcohols is reported which leads to 5a-i in aqueous media. Replacing the primary alcohol with isopropyl alcohol and tert-butyl alcohol results in different products 10 and 11. The environmentally friendly features, good to high yields and easy ...

background: in asia pacific (ap) region, the exact picture of the alcohol use problems has remained relatively obscure. in this study, the profile of alcohol consumption and alcohol related disorders in ap countries are presented.     methods: official statistics on average alcohol consumption (alcohol per capita consumption, apc), alcohol related health variables, income group and alcohol poli...

Mutants of the methylotrophic actinomycete Amycolaropsis methanolica unable to grow on methanol as carbon source were isolated and characterized. Mutants specifically affected in methanol utilization were deficient in formaldehyde assimilation. Mutants blocked in the first step of primary alcohol oxidation (Cl-C4) had lost activity of the tetrazolium-dependent alcohol dehydrogenase, a three-com...

BACKGROUND There is a need for primary care providers to have brief effective methods to intervene with high-risk drinkers during a regular outpatient visit. OBJECTIVE To determine whether brief physician- and nurse practitioner-delivered counseling intervention is efficacious as part of routine primary care in reducing alcohol consumption by high-risk drinkers. METHODS Academic medical cen...

OBJECTIVE This study compared the severity of and the change in depressive symptoms among men with alcohol dependence, affective disorder, or both disorders during 4 weeks of inpatient treatment. METHOD After their primary and secondary psychiatric disorders were defined with the use of criteria based on chronology of symptoms, 54 unmedicated men entering treatment for alcohol dependence or a...

Prenatal alcohol exposure is associated with a range of negative cognitive outcomes in children, including, frequently, impaired verbal learning and memory. The aim if the current research was to replicate previous findings on the effects of heavy prenatal alcohol exposure on verbal learning and memory, as well as elaborate on previous research including children with moderate prenatal alcohol ...

Alcohol consumption is an established risk factor, and also a potential prognostic factor, for squamous cell carcinoma of the head and neck (HNSCC). However, little is known about whether the prognostic impact of alcohol consumption differs by treatment method. We evaluated the association between alcohol drinking and survival by treatment method to the primary site in 427 patients with HNSCC t...

OBJECTIVE The current cross sectional study sought to examine whether perceived social normative beliefs are associated with indicators of alcohol use in a sample of alcohol misusing veterans. METHOD A sample of 107 U.S. Military Veterans presenting to primary care that screened positive for alcohol misuse on the alcohol use disorders identification test-consumption items (AUDIT-C) was recrui...