Interactions between RNA binding proteins (RBPs) and mRNAs are critical to post-transcriptional gene regulation. Eukaryotic genomes encode thousands of mRNAs and hundreds of RBPs. However, in contrast to interactions between transcription factors (TFs) and DNA, the interactome between RBPs and RNA has been explored for only a small number of proteins and RNAs. This is largely because the focus ...

In this paper, I argue that the temporal connective prima (‘before’) is a comparative adverb. The argument is based on a number of grammatical facts from Italian, showing that there is an asymmetry between prima and dopo (‘after’). On the ground of their divergent behaviour, I suggest that dopo has a different grammatical status from prima. I propose a semantic treatment for prima that is based...

OBJECTIVES Bladder cancer represents 3% of all carcinomas in the Brazilian population and ranks second in incidence among urological tumors, after prostate cancer. The loss of p53 function is the main genetic alteration related to the development of high-grade muscle-invasive disease. Prima-1 is a small molecule that restores tumor suppressor function to mutant p53 and induces cancer cell death...

AIM This paper presents the development process of the European framework for psychosocial risk management (PRIMA-EF). It also summarises and discusses key findings of research conducted through this policy-orientated research programme. OBJECTIVES This paper presents an overview of the development process of PRIMA-EF. The background, methods and outcomes are described and discussed. The pape...

This year marks the 100th year anniversary of when Nik olai Anichkov firs t used the rabbit model to show that the ingestion of dietary cholesterol alone is a primary cause of atheroscleros is. Since 1913 it has been demonstrated in thousa nds of animal experiments that the feeding of cholesterol, including in the form of fresh egg yolk accelerates the development of a theroscler osis in virtua...

This paper focuses on a puzzling asymmetry which arises when the Italian approximative adverb quasi ‘almost’ modifies the temporal connectives prima ‘before’ and dopo ‘after’. By looking at naturally occurring data, we observe that A quasi prima che B ‘A almost before B’ can be used to convey that an Aeventuality occurs early, only a little bit after a B-eventuality occurs. Consider the sentenc...

BACKGROUND Multimorbidity is increasing in aging populations with a corresponding increase in polypharmacy as well as inappropriate prescribing. Depending on definitions, 25-50 % of patients aged 75 years or older are exposed to at least five drugs. Evidence is increasing that polypharmacy, even when guidelines advise the prescribing of each drug individually, can potentially cause more harm th...

It is now mandatory for healthcare organizations to specify and publish their privacy policies. This has made privacy management initiatives in the healthcare sector increasingly important. However, several recent reports in the public media and the research community about healthcare privacy [1, 2] indicate that the use of privacy policies is not necessarily a strong indication of adequate pri...

Jerome wrote Epistula prima probably during the decade of 366–376. Little is known about this stage in his life, but it was apparently then that as a young man he became interested asceticism and at end period time finally decided to become monk. However, ascetic ideas are not main theme Ep. 1. The letter tells story falsely accused woman who subjected torture survived seven strokes executioner...

Symbolic Model Order Reduction (SMOR) is the problem of reducing a large circuit that contains symbolic circuit parameters to smaller low order models at its ports. Several methods, including symbol isolation, single frequency point reduction, and multiple frequency point reduction, are described and compared. Test circuits with simulation results are presented to demonstrate the accuracy and e...